Literature DB >> 2870725

Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate.

W Koek, E Kleer, P J Mudar, J H Woods.   

Abstract

This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that DL-2-amino-5-phosphonovalerate, a selective NMA antagonist, produces phencyclidine-like catalepsy in pigeons. This finding suggests the possibility that other behavioral actions of phencyclidine-like substances may be mediated in a similar fashion.

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Year:  1986        PMID： 2870725     DOI： 10.1016/0166-4328(86)90026-4

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  9 in total

1.  Effects of MK-801, a non-competitive NMDA antagonist, on linguopharyngeal events in rats.

Authors:  L A Marco; R S Joshi; R B Chronister
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

2.  Is the discriminative stimulus produced by phencyclidine due to an interaction with N-methyl-D-aspartate receptors?

Authors:  A Jackson; D J Sanger
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

3.  Response repetition in pigeons: pharmacological and behavioral specificity.

Authors:  W Koek; J H Woods
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

4.  Effects of phencyclidine, SKF 10,047 and related psychotomimetic agents on N-methyl-D-aspartate receptor mediated synaptic responses in rat hippocampal slices.

Authors:  E J Coan; G L Collingridge
Journal:  Br J Pharmacol       Date:  1987-07       Impact factor: 8.739

5.  Immediate and long-lasting effects of MK-801 on motor activity, spatial navigation in a swimming pool and EEG in the rat.

Authors:  I Q Whishaw; R N Auer
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

6.  Discriminative stimulus effects of a centrally administered, delta-opioid peptide (D-Pen2-D-Pen5-enkephalin) in pigeons.

Authors:  D C Jewett; H I Mosberg; J H Woods
Journal:  Psychopharmacology (Berl)       Date:  1996-10       Impact factor: 4.530

7.  A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats.

Authors:  W Koek; J H Woods; P Ornstein
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

Review 8.  Phencyclidine. Physiological actions, interactions with excitatory amino acids and endogenous ligands.

Authors:  P C Contreras; J B Monahan; T H Lanthorn; L M Pullan; D A DiMaggio; G E Handelmann; N M Gray; T L O'Donohue
Journal:  Mol Neurobiol       Date:  1987       Impact factor: 5.590

9.  Phencyclidine (PCP)-like discriminative stimulus effects of metaphit and of 2-amino-5-phosphonovalerate in pigeons: generality across different training doses of PCP.

Authors:  W Koek; J H Woods; A E Jacobson; K C Rice
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
  9 in total

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