Y Karabağ1, I Rencuzogullari2, M Çağdaş1, S Karakoyun1, M Yesin3, M Uluganyan4, M O Gürsoy5, İnanç Artaç1, Doğan İliş1, Tayyar Gökdeniz6, S Ç Efe7, O Taşar8, H I Tanboğa9. 1. Department of Cardiology, Kafkas University Medical Faculty, Kars, Turkey. 2. Department of Cardiology, Kafkas University Medical Faculty, Kars, Turkey. rencuzog@gmail.com. 3. Department of Cardiology, Kars Harakani State Hospital, Kars, Turkey. 4. Department of Cardiology, Yedikule Chest Diseases and Chest Surgery Education and Research Center, Istanbul, Turkey. 5. Department of Cardiology, Gaziemir State Hospital, İzmir, Turkey. 6. Department of Cardiology, Medipol University Medical Faculty, İstanbul, Turkey. 7. Department of Cardiology, Ağrı State Hospital, Ağrı, Turkey. 8. Department of Cardiology, Elazığ Education and Research Hospital, Elazığ, Turkey. 9. Department of Cardiology, Ataturk University Medical Faculty, Erzurum, Turkey.
Abstract
BACKGROUND: New-onset atrial fibrillation (NOAF), a common complication of acute ST-segment elevation myocardial infarction (STEMI), is associated with a poor prognosis. Several clinical and laboratory parameters are reported to be associated with NOAF in patients with STEMI. The aim of the present study was to evaluate the predictive value of plasma B‑type natriuretic peptide (BNP) levels for NOAF development and long-term prognosis in STEMI patients undergoing primary percutaneous coronary intervention (pPCI). PATIENTS AND METHODS: We retrospectively enrolled 1,928 patients with STEMI who underwent pPCI. After applying exclusion criteria, 1,057 patients were retained in the final study population. Patients with NOAF were compared with patients without NOAF in the entire study population and in a matched group. RESULTS: Patients with NOAF had a significantly higher average plasma BNP level (161 pg/ml, range: 72.3-432) than patients without NOAF in the study population (70.7 pg/ml, range: 70-129; p < 0.001) and in the matched group (104.6 pg/ml, range: 47.2-234.5; p = 0.014). Furthermore, the plasma BNP level was found to be an independent predictor of NOAF development (odds ratio [OR]: 1.003; 95% confidence interval [CI]: 1.000-1.005; p = 0.034) and mortality in the long-term follow-up (OR: 1.004; 95% CI: 1.002-1.006; p < 0.001). CONCLUSION: The present study found that a high plasma BNP level was significantly associated with NOAF development in STEMI patients, and was an independent predictor of NOAF development and all-cause mortality during long-term follow-up, regardless of other NOAF risk factors.
BACKGROUND: New-onset atrial fibrillation (NOAF), a common complication of acute ST-segment elevation myocardial infarction (STEMI), is associated with a poor prognosis. Several clinical and laboratory parameters are reported to be associated with NOAF in patients with STEMI. The aim of the present study was to evaluate the predictive value of plasma B‑type natriuretic peptide (BNP) levels for NOAF development and long-term prognosis in STEMI patients undergoing primary percutaneous coronary intervention (pPCI). PATIENTS AND METHODS: We retrospectively enrolled 1,928 patients with STEMI who underwent pPCI. After applying exclusion criteria, 1,057 patients were retained in the final study population. Patients with NOAF were compared with patients without NOAF in the entire study population and in a matched group. RESULTS:Patients with NOAF had a significantly higher average plasma BNP level (161 pg/ml, range: 72.3-432) than patients without NOAF in the study population (70.7 pg/ml, range: 70-129; p < 0.001) and in the matched group (104.6 pg/ml, range: 47.2-234.5; p = 0.014). Furthermore, the plasma BNP level was found to be an independent predictor of NOAF development (odds ratio [OR]: 1.003; 95% confidence interval [CI]: 1.000-1.005; p = 0.034) and mortality in the long-term follow-up (OR: 1.004; 95% CI: 1.002-1.006; p < 0.001). CONCLUSION: The present study found that a high plasma BNP level was significantly associated with NOAF development in STEMI patients, and was an independent predictor of NOAF development and all-cause mortality during long-term follow-up, regardless of other NOAF risk factors.
Authors: J A de Lemos; D A Morrow; J H Bentley; T Omland; M S Sabatine; C H McCabe; C Hall; C P Cannon; E Braunwald Journal: N Engl J Med Date: 2001-10-04 Impact factor: 91.245
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Authors: Marco V Perez; Paul J Wang; Joseph C Larson; Elsayed Z Soliman; Marian Limacher; Beatriz Rodriguez; Liviu Klein; Joann E Manson; Lisa W Martin; Ronald Prineas; Stephanie Connelly; Mark Hlatky; Sylvia Wassertheil-Smoller; Marcia L Stefanick Journal: Heart Date: 2013-06-11 Impact factor: 5.994