Rajeev Ranjan1, Sudhir R Patil2, Veena H R2. 1. Department of Periodontics and Oral Implantology, Kalinga Institute of Dental Sciences, Campus 5, KIIT University, Patia, Bhubaneswar, Odisha, 751024, India. 2. Department of Periodontics, K.L.E Society's Institute of Dental Sciences, Number 20, Tumkur Road, Yeshavanthpur Suburbs, suburb Bangalore, 560022, India.
Abstract
BACKGROUND: The present randomized controlled clinical study was designed to investigate the effect of in situ application of 1.2 mg Simvastatin (SV) gel in the surgical management of Intrabony defects in chronic periodontitis patients. METHODOLOGY:20 patients contributing 40 sites were categorized into two treatment groups: Open flap debridement plus 1.2 mg SV gel (Group 1) and Open flap debridement plus Placebo gel (Group 2). Gingival index (GI), Plaque index (PI), Pocket depth (PD) and clinical attachment level (CAL) were recorded at baseline, 3 months, 6 months and 9 months. At baseline and at the end of 6 and 9 months Radiographic evaluation of Intrabony defect fill was done using Image j software. RESULTS: Significant reduction of GI, PD and gain in CAL was observed at the end of 9 months in both groups. Amount of bone fill and percentage of original defect fill in Group 1 was statistically highly significant than Group 2 at the end of 6 and 9 months. CONCLUSION: Higher amount of decrease in GI and PD along with more amount of CAL gain was observed in treatment group than control group. Radiological assessment confirmed that significant intrabony defect fill and percentage fill of original defect in treatment group than controlled group.
RCT Entities:
BACKGROUND: The present randomized controlled clinical study was designed to investigate the effect of in situ application of 1.2 mg Simvastatin (SV) gel in the surgical management of Intrabony defects in chronic periodontitispatients. METHODOLOGY: 20 patients contributing 40 sites were categorized into two treatment groups: Open flap debridement plus 1.2 mg SV gel (Group 1) and Open flap debridement plus Placebo gel (Group 2). Gingival index (GI), Plaque index (PI), Pocket depth (PD) and clinical attachment level (CAL) were recorded at baseline, 3 months, 6 months and 9 months. At baseline and at the end of 6 and 9 months Radiographic evaluation of Intrabony defect fill was done using Image j software. RESULTS: Significant reduction of GI, PD and gain in CAL was observed at the end of 9 months in both groups. Amount of bone fill and percentage of original defect fill in Group 1 was statistically highly significant than Group 2 at the end of 6 and 9 months. CONCLUSION: Higher amount of decrease in GI and PD along with more amount of CAL gain was observed in treatment group than control group. Radiological assessment confirmed that significant intrabony defect fill and percentage fill of original defect in treatment group than controlled group.
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