Kristine Bech Holte1, Niels Gunnar Juel2, Jens Ivar Brox3, Kristian Folkvord Hanssen4, Dag Sigurd Fosmark5, David R Sell6, Vincent M Monnier6, Tore Julsrud Berg7. 1. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Post Box 4956, Nydalen, 0424 Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postboks 1078, Blindern, 0316 Oslo, Norway. Electronic address: k.b.holte@medisin.uio.no. 2. Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Post Box 4956, Nydalen, 0424 Oslo, Norway. 3. Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Post Box 4956, Nydalen, 0424 Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postboks 1078, Blindern, 0316 Oslo, Norway. 4. The Norwegian Diabetics' Center, Sponhoggveien 19, 0284 Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postboks 1078, Blindern, 0316 Oslo, Norway. 5. Department of Ophthalmology, Oslo University Hospital, Post Box 4956, Nydalen, 0424 Oslo, Norway. 6. Department of Pathology, Case Western Reserve University School of Medicine, 2109 Adelbert Rd, Cleveland, OH 44106, USA. 7. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Post Box 4956, Nydalen, 0424 Oslo, Norway; The Norwegian Diabetics' Center, Sponhoggveien 19, 0284 Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postboks 1078, Blindern, 0316 Oslo, Norway.
Abstract
AIMS: We aimed to: (i) estimate the prevalence of Dupuytren's disease, trigger finger, carpal tunnel syndrome and frozen shoulder; (ii) assess stiffness of the hand, shoulder and back; and (iii) explore the association of joint stiffness with both long-term HbA1c and collagen advanced glycation end-products (AGEs) in long-term type 1 diabetes mellitus (T1DM). METHODS: Patients with T1DM from 1970 or earlier attending a specialized diabetes center were included in this cross-sectional controlled study. We collected HbA1/HbA1c measurements from 1980 to 2015 and data on hand and shoulder diagnoses and joint stiffness through interviews, charts, and standardized examination. Skin biopsies were analyzed for collagen AGEs by liquid chromatography-mass spectrometry. RESULTS: Lifetime prevalence of hand and shoulder diagnoses in the diabetes group (n=102) ranged from 37%-76% (frozen shoulder) versus 11%-15% in controls (n=73) (p<0.001). There was an association between joint stiffness and long-term HbA1c (odds ratio 2.01 [95% CI 1.10-3.7]) and the AGEs methyl-glyoxal-lysine-dimer (odds ratio 1.68 [95% CI 1.03-2.73]) and pentosidine (odds ratio 1.81 [95% CI 1.04-3.16]). CONCLUSIONS: Patients with T1DM >45years had a very high prevalence of hand and shoulder diagnoses versus controls. Joint stiffness was associated with collagen AGEs. However, joint biopsies and prospective studies must explore this association further.
AIMS: We aimed to: (i) estimate the prevalence of Dupuytren's disease, trigger finger, carpal tunnel syndrome and frozen shoulder; (ii) assess stiffness of the hand, shoulder and back; and (iii) explore the association of joint stiffness with both long-term HbA1c and collagen advanced glycation end-products (AGEs) in long-term type 1 diabetes mellitus (T1DM). METHODS:Patients with T1DM from 1970 or earlier attending a specialized diabetes center were included in this cross-sectional controlled study. We collected HbA1/HbA1c measurements from 1980 to 2015 and data on hand and shoulder diagnoses and joint stiffness through interviews, charts, and standardized examination. Skin biopsies were analyzed for collagen AGEs by liquid chromatography-mass spectrometry. RESULTS: Lifetime prevalence of hand and shoulder diagnoses in the diabetes group (n=102) ranged from 37%-76% (frozen shoulder) versus 11%-15% in controls (n=73) (p<0.001). There was an association between joint stiffness and long-term HbA1c (odds ratio 2.01 [95% CI 1.10-3.7]) and the AGEs methyl-glyoxal-lysine-dimer (odds ratio 1.68 [95% CI 1.03-2.73]) and pentosidine (odds ratio 1.81 [95% CI 1.04-3.16]). CONCLUSIONS:Patients with T1DM >45years had a very high prevalence of hand and shoulder diagnoses versus controls. Joint stiffness was associated with collagen AGEs. However, joint biopsies and prospective studies must explore this association further.
Authors: Kerstin Gutefeldt; Simon Lundstedt; Ingrid S M Thyberg; Margareta Bachrach-Lindström; Hans J Arnqvist; Anna Spångeus Journal: J Diabetes Res Date: 2020-03-11 Impact factor: 4.011
Authors: Kari Anne Sveen; Kristine Bech Holte; Mona Svanteson; Kristian F Hanssen; Jan Nilsson; Eva Bengtsson; Tore Julsrud Berg Journal: Diabetes Care Date: 2021-04-15 Impact factor: 19.112