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Literature DB >> 2870468

Effects of phorbol ester on spontaneous transmitter release at frog neuromuscular junction.

Abstract

Spontaneous transmitter release was studied at frog neuromuscular junctions exposed to the tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA), a specific activator of protein kinase C (PrkC). TPA at concentrations between 10(-7) and 10(-6) M induced a dose-dependent increase in miniature end-plate potential frequency. This frequency increase was enhanced by raising [Ca]o, diminished by lowering the temperature of the bath and virtually abolished in Ca2+ -free Ringer. The TPA effect was only poorly reversible after washing. TPA was ineffective in increasing spontaneous release of transmitter at phosphatidylcholine-pretreated neuromuscular junctions. It is suggested that PrkC might play a role in neuromuscular transmission processes.

Entities: Chemical Disease

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Year: 1986 PMID： 2870468 DOI： 10.1007/bf00586680

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

11 in total

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14 in total

1. Stimulation of spontaneous transmitter release at the frog neuromuscular junction by 12-O-tetradecanoylphorbol-13-acetate occurs in the absence of extracellular Ca2+ and is enhanced by depolarization.

Authors: P E Light; Z Y Sahaf; S J Publicover
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1988-10 Impact factor: 3.000

2. Effects of phorbol dibutyrate on M currents and M current inhibition in bullfrog sympathetic neurons.

Authors: D A Brown; P R Adams
Journal: Cell Mol Neurobiol Date: 1987-09 Impact factor: 5.046

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Authors: S Austin; J McGivern; C N Scholfield
Journal: Br J Pharmacol Date: 1991-01 Impact factor: 8.739

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Authors: T S Sihra; R A Nichols
Journal: Neurochem Res Date: 1993-01 Impact factor: 3.996

5. A phorbol diester-induced enhancement of synaptic transmission in olfactory cortex.

Authors: C N Scholfield; A J Smith
Journal: Br J Pharmacol Date: 1989-12 Impact factor: 8.739

6. Activation of protein kinase C potentiates postsynaptic acetylcholine response at developing neuromuscular synapses.

Authors: W M Fu; J L Lin
Journal: Br J Pharmacol Date: 1993-10 Impact factor: 8.739

7. Effects of diacylglycerol and phorbol ester on acetylcholine release and action at the neuromuscular junction in mice.

Authors: R L Murphy; M E Smith
Journal: Br J Pharmacol Date: 1987-02 Impact factor: 8.739

8. The phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate, enhances the evoked quanta release of acetylcholine at the frog neuromuscular junction.

Authors: C Haimann; J Meldolesi; B Ceccarelli
Journal: Pflugers Arch Date: 1987-01 Impact factor: 3.657

9. Postsynaptic effects of the phorbol ester TPA on frog end-plates.

Authors: C G Caratsch; F Grassi; M Molinaro; F Eusebi
Journal: Pflugers Arch Date: 1986-10 Impact factor: 3.657

10. Influence of protein kinase C-stimulation by a phorbol ester on neurotransmitter release at frog end-plates.

Authors: C G Caratsch; S Schumacher; F Grassi; F Eusebi
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1988-01 Impact factor: 3.000