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Correction: In Vivo Persistence of Human Rhinoviruses in Immunosuppressed Patients.

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Abstract

[This corrects the article DOI: 10.1371/journal.pone.0170774.].

Entities:  

Year:  2017        PMID: 28704567      PMCID: PMC5509319          DOI: 10.1371/journal.pone.0181296

Source DB:  PubMed          Journal:  PLoS One        ISSN: 1932-6203            Impact factor:   3.240


The legends for Figs 1 and 2 incorrectly appear within the body of the article. The legend for Fig 1 incorrectly appears above the "Detection of respiratory viruses" heading of the Methods section. The legend for Fig 2 incorrectly appears above the “Statistical analysis” heading of the Methods section. There are errors in the caption for Fig 1. Please see the complete, correct captions for Figs 1 and 2 here. The publisher apologizes for the error.
Fig 1

Flow diagram for patients and specimens included in the study.

HRV++: detection of HRV/enterovirus in two or more respiratory specimens

HRV++ ≥ 45 days: detection of HRV/enterovirus in two or more respiratory specimens that were taken at an interval of 45 days or more

HRV +-: specimen with detection of HRV/enterovirus followed by a specimen without HRV/enterovirus detection

HRV +- (3–44 days apart): specimen with detection of HRV/enterovirus followed by a specimen without HRV/enterovirus detection taken between 3 and 44 days after the positive specimen

HRV +- (≥ 45 days apart): specimen with detection of HRV/enterovirus followed by a specimen without HRV/enterovirus detection taken 45 days or more after the positive specimen

HRV-+: specimen without HRV/enterovirus detection followed by a specimen with HRV/enterovirus detection

HRV--: all specimens were negative for HRV/enterovirus

Grey shading indicates the groups that are shown in table 1.

Fig 2

Phylogenetic analysis of the nucleotide sequences of the HRV/enterovirus VP4/VP2 region.

A neighbour joining tree of partial VP4/VP2 sequences was constructed by using MEGA 6 [27]. The numbers indicate the patients and the letters the specimens, with A being the first chronologically. Coxsackievirus A21 was used as out-group. The percentage of bootstraps (out of 1000) that supports the corresponding clade is shown at the nodes if higher than 70%. HRV-A, -B and -C and Coxsackievirus A21 reference sequences were included. The scale bar indicates nucleotide substitutions per site. Persistent infections are indicated with a black square. GenBank accession numbers of the sequences obtained in this study are indicated in S1 Text.

In patient 53, the first two specimens were unavailable for typing, therefore only specimens 53C to G are reported.

Flow diagram for patients and specimens included in the study.

HRV++: detection of HRV/enterovirus in two or more respiratory specimens HRV++ ≥ 45 days: detection of HRV/enterovirus in two or more respiratory specimens that were taken at an interval of 45 days or more HRV +-: specimen with detection of HRV/enterovirus followed by a specimen without HRV/enterovirus detection HRV +- (3–44 days apart): specimen with detection of HRV/enterovirus followed by a specimen without HRV/enterovirus detection taken between 3 and 44 days after the positive specimen HRV +- (≥ 45 days apart): specimen with detection of HRV/enterovirus followed by a specimen without HRV/enterovirus detection taken 45 days or more after the positive specimen HRV-+: specimen without HRV/enterovirus detection followed by a specimen with HRV/enterovirus detection HRV--: all specimens were negative for HRV/enterovirus Grey shading indicates the groups that are shown in table 1.

Phylogenetic analysis of the nucleotide sequences of the HRV/enterovirus VP4/VP2 region.

A neighbour joining tree of partial VP4/VP2 sequences was constructed by using MEGA 6 [27]. The numbers indicate the patients and the letters the specimens, with A being the first chronologically. Coxsackievirus A21 was used as out-group. The percentage of bootstraps (out of 1000) that supports the corresponding clade is shown at the nodes if higher than 70%. HRV-A, -B and -C and Coxsackievirus A21 reference sequences were included. The scale bar indicates nucleotide substitutions per site. Persistent infections are indicated with a black square. GenBank accession numbers of the sequences obtained in this study are indicated in S1 Text. In patient 53, the first two specimens were unavailable for typing, therefore only specimens 53C to G are reported.
  1 in total

1.  In Vivo Persistence of Human Rhinoviruses in Immunosuppressed Patients.

Authors:  Ilka Engelmann; Anny Dewilde; Mouna Lazrek; Mathilde Batteux; Aminati Hamissi; Ibrahim Yakoub-Agha; Didier Hober
Journal:  PLoS One       Date:  2017-02-02       Impact factor: 3.240

  1 in total

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