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Abstract
[This corrects the article DOI: 10.1371/journal.pone.0170774.].Entities:
Year: 2017 PMID: 28704567 PMCID: PMC5509319 DOI: 10.1371/journal.pone.0181296
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Fig 1Flow diagram for patients and specimens included in the study.
HRV++: detection of HRV/enterovirus in two or more respiratory specimens
HRV++ ≥ 45 days: detection of HRV/enterovirus in two or more respiratory specimens that were taken at an interval of 45 days or more
HRV +-: specimen with detection of HRV/enterovirus followed by a specimen without HRV/enterovirus detection
HRV +- (3–44 days apart): specimen with detection of HRV/enterovirus followed by a specimen without HRV/enterovirus detection taken between 3 and 44 days after the positive specimen
HRV +- (≥ 45 days apart): specimen with detection of HRV/enterovirus followed by a specimen without HRV/enterovirus detection taken 45 days or more after the positive specimen
HRV-+: specimen without HRV/enterovirus detection followed by a specimen with HRV/enterovirus detection
HRV--: all specimens were negative for HRV/enterovirus
Grey shading indicates the groups that are shown in table 1.
Fig 2Phylogenetic analysis of the nucleotide sequences of the HRV/enterovirus VP4/VP2 region.
A neighbour joining tree of partial VP4/VP2 sequences was constructed by using MEGA 6 [27]. The numbers indicate the patients and the letters the specimens, with A being the first chronologically. Coxsackievirus A21 was used as out-group. The percentage of bootstraps (out of 1000) that supports the corresponding clade is shown at the nodes if higher than 70%. HRV-A, -B and -C and Coxsackievirus A21 reference sequences were included. The scale bar indicates nucleotide substitutions per site. Persistent infections are indicated with a black square. GenBank accession numbers of the sequences obtained in this study are indicated in S1 Text.
In patient 53, the first two specimens were unavailable for typing, therefore only specimens 53C to G are reported.