Literature DB >> 28704201

IL-17 and Th17 cells in systemic sclerosis: a comprehensive review.

Paul Bălănescu1, Eugenia Bălănescu1, Anca Bălănescu1.   

Abstract

T cells (especially T helper cells) seem to be strongly associated with systemic sclerosis pathogenesis. Th17-IL-17 axis was proved to be involved in the pathogenesis of multiple autoimmune diseases. By performing a comprehensive research of the literature indexed in PubMed database, the current review summarizes current knowledge related to Th17 and IL-17 in systemic sclerosis. While there is promising data suggesting inhibition of Tregulatory and Th1 signals on one hand and promotion of Th17 and Th2 signals on the other, studies that include prospective and integrated analysis of Tregulatory, Th17, Th1, Th2 (cells and derived cytokines) on the same cohort of Ssc patients are warranted.

Entities:  

Keywords:  IL-17A; IL-17F; Systemic sclerosis; Th17

Mesh：

Substances：

Year:  2017        PMID： 28704201     DOI： 10.1515/rjim-2017-0027

Source DB:  PubMed          Journal:  Rom J Intern Med        ISSN： 1220-4749


  7 in total

Review 1.  The Yin and Yang of IL-17 in Systemic Sclerosis.

Authors:  Lanxuan Wei; David Abraham; Voon Ong
Journal:  Front Immunol       Date:  2022-05-04       Impact factor: 8.786

2.  Gastric Juice Expression of Th-17 and T-Reg Related Cytokines in Scleroderma Esophageal Involvement.

Authors:  Stefania Nicola; Giovanni Rolla; Caterina Bucca; Giada Geronazzo; Irene Ridolfi; Andrea Ferraris; Enrico Fusaro; Clara Lisa Peroni; Luca Dughera; Luisa Brussino
Journal:  Cells       Date:  2020-09-16       Impact factor: 6.600

3.  Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts.

Authors:  Jeonghyeon Moon; Seon-Yeong Lee; Jeong Won Choi; A Ram Lee; Jin Hee Yoo; Su-Jin Moon; Sung-Hwan Park; Mi-La Cho
Journal:  J Transl Med       Date:  2021-05-04       Impact factor: 5.531

Review 4.  Advances in Potential Cerebrospinal Fluid Biomarkers for Autoimmune Encephalitis: A Review.

Authors:  Shuyu Zhang; Chengyuan Mao; Xinwei Li; Wang Miao; Junfang Teng
Journal:  Front Neurol       Date:  2022-07-22       Impact factor: 4.086

Review 5.  The Involvement of Smooth Muscle, Striated Muscle, and the Myocardium in Scleroderma: A Review.

Authors:  Ioana Bratoiu; Alexandra Maria Burlui; Anca Cardoneanu; Luana Andreea Macovei; Patricia Richter; Gabriela Rusu-Zota; Ciprian Rezus; Minerva Codruta Badescu; Andreea Szalontay; Elena Rezus
Journal:  Int J Mol Sci       Date:  2022-10-09       Impact factor: 6.208

6.  Icaritin Inhibits Skin Fibrosis through Regulating AMPK and Wnt/β-catenin Signaling.

Authors:  Ming Li; Qingmei Liu; Shan He; Xiangzhen Kong; Jinpei Lin; Yan Huang; Wenyu Wu; Jinfeng Wu
Journal:  Cell Biochem Biophys       Date:  2020-10-30       Impact factor: 2.194

7.  Impact of Human Cytomegalovirus and Human Herpesvirus 6 Infection on the Expression of Factors Associated with Cell Fibrosis and Apoptosis: Clues for Implication in Systemic Sclerosis Development.

Authors:  Maria-Cristina Arcangeletti; Maria D'Accolti; Clara Maccari; Irene Soffritti; Flora De Conto; Carlo Chezzi; Adriana Calderaro; Clodoveo Ferri; Elisabetta Caselli
Journal:  Int J Mol Sci       Date:  2020-09-03       Impact factor: 5.923
  7 in total

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