Literature DB >> 28703729

A Case of Decreased Susceptibility to Ceftriaxone in Neisseria gonorrhoeae in the Absence of a Mosaic Penicillin-Binding Protein 2 (penA) Allele.

A Jeanine Abrams1, Robert D Kirkcaldy, Kevin Pettus, Jan L Fox, Grace Kubin, David L Trees.   

Abstract

We report a case of Neisseria gonorrhoeae with a non-mosaic penA allele that exhibited decreased susceptibility to extended-spectrum cephalosporins, including a ceftriaxone minimum inhibitory concentration of 0.5 μg/mL. An analysis of resistance determinants suggested that the observed phenotype might have resulted from the combined effects of mutations in multiple genes.

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Year:  2017        PMID： 28703729      PMCID： PMC6932624          DOI： 10.1097/OLQ.0000000000000645

Source DB:  PubMed          Journal:  Sex Transm Dis        ISSN： 0148-5717            Impact factor:   2.830


  16 in total

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Journal:  J Comput Biol       Date:  2012-04-16       Impact factor: 1.479

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8.  Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA.

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10.  Genomic epidemiology of Neisseria gonorrhoeae with reduced susceptibility to cefixime in the USA: a retrospective observational study.

Authors:  Yonatan H Grad; Robert D Kirkcaldy; David Trees; Janina Dordel; Simon R Harris; Edward Goldstein; Hillard Weinstock; Julian Parkhill; William P Hanage; Stephen Bentley; Marc Lipsitch
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  10 in total

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