Andrew Moore1, Anne Crossley2, Bernard Ng2, Lawrence Phillips3, Özgür Sancak2, K D Rainsford4. 1. Pain Research, Nuffield Division of Anaesthetics, University of Oxford, Oxford, UK. 2. Reckitt Benckiser Consumer Health, Slough, UK. 3. Department of Management, London School of Economics and Political Science, London, UK. 4. Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK.
Abstract
OBJECTIVES: To test the ability of a multicriteria decision analysis (MCDA) model to incorporate disparate data sources of varying quality along with clinical judgement in a benefit-risk assessment of six well-known pain-relief drugs. METHODS: Six over-the-counter (OTC) analgesics were evaluated against three favourable effects and eight unfavourable effects by seven experts who specialise in the relief of pain, two in a 2-day facilitated workshop whose input data and judgements were later peer-reviewed by five additional experts. KEY FINDINGS: Ibuprofen salts and solubilised emerged with the best benefit-risk profile, followed by naproxen, ibuprofen acid, diclofenac, paracetamol and aspirin. CONCLUSIONS: Multicriteria decision analysis enabled participants to evaluate the OTC analgesics against a range of favourable and unfavourable effects in a group setting that enabled all issues to be openly aired and debated. The model was easily communicated and understood by the peer reviewers, so the model should be comprehensible to physicians, pharmacists and other health professionals.
OBJECTIVES: To test the ability of a multicriteria decision analysis (MCDA) model to incorporate disparate data sources of varying quality along with clinical judgement in a benefit-risk assessment of six well-known pain-relief drugs. METHODS: Six over-the-counter (OTC) analgesics were evaluated against three favourable effects and eight unfavourable effects by seven experts who specialise in the relief of pain, two in a 2-day facilitated workshop whose input data and judgements were later peer-reviewed by five additional experts. KEY FINDINGS:Ibuprofen salts and solubilised emerged with the best benefit-risk profile, followed by naproxen, ibuprofen acid, diclofenac, paracetamol and aspirin. CONCLUSIONS: Multicriteria decision analysis enabled participants to evaluate the OTC analgesics against a range of favourable and unfavourable effects in a group setting that enabled all issues to be openly aired and debated. The model was easily communicated and understood by the peer reviewers, so the model should be comprehensible to physicians, pharmacists and other health professionals.
Authors: Stephan Schug; Esther Pogatzki-Zahn; Lawrence D Phillips; Margaret Noyes Essex; Feng Xia; Alison J Reader; Robert Pawinski Journal: J Pain Res Date: 2020-08-05 Impact factor: 3.133
Authors: Anne Katrin Schlag; David S Baldwin; Michael Barnes; Steve Bazire; Rachel Coathup; H Valerie Curran; Rupert McShane; Lawrence D Phillips; Ilina Singh; David J Nutt Journal: J Psychopharmacol Date: 2020-06-10 Impact factor: 4.153
Authors: David J Nutt; Lawrence D Phillips; Michael P Barnes; Brigitta Brander; Helen Valerie Curran; Alan Fayaz; David P Finn; Tina Horsted; Julie Moltke; Chloe Sakal; Haggai Sharon; Saoirse E O'Sullivan; Tim Williams; Gregor Zorn; Anne K Schlag Journal: Cannabis Cannabinoid Res Date: 2021-03-17