Literature DB >> 28702828

Evaluating the perioperative safety of laparoscopic radical nephrectomy for large, non-metastatic renal tumours: a comparative analysis of T1-T2 with T3a tumours.

E M Bolton1, D Hennessy2, P E Lonergan2, F T Darcy2, R P Manecksha2, T H Lynch2.   

Abstract

OBJECTIVE: With increasing surgeon experience, the use of laparoscopic radical nephrectomy (LRN) in large and locally advanced renal tumours (T3a) is gaining favour in urological practice. There are limited studies reporting surgical outcomes in such groups. The aim of this study was to review our experience with LRN in these patients.
METHODS: Data was retrospectively collected on 201 consecutive patients who underwent LRN for renal cancer by a single surgeon. Perioperative parameters assessed were age, gender, American Society of Anaesthesiologists score (ASA), waist circumference, tumour size, specimen size, histological subtypes, anaesthetic duration, operative approach and technique, surgery duration, blood loss, pre and postoperative renal function, complication rate and duration of hospital stay.
RESULTS: Of 201 patients undergoing LRN, 43 (21%) patients had T3a tumours (group 2). The remaining 158 (79%) patients had T1 tumours (group1). Mean tumour size in group 2 was 12.2 cm. Renal cell carcinoma (RCC) was more common in males than females (131/201; 65%). Patients with T3a disease were more likely to have an ASA score of 2 (37/201; 18%). In the majority of patients across both groups, LRN was completed using a 3-port approach (173/201; 86%). There were no significant differences between groups in terms of mean anaesthetic duration, average surgical time, average estimated blood loss, complication rate and mean hospital stay.
CONCLUSION: Our study shows that LRN has equivalent perioperative outcomes and safety in larger and locally advanced renal tumours.

Entities:  

Keywords:  Laparoscopic nephrectomy; Renal cancer; Surgical outcomes; T3a tumours

Mesh:

Year:  2017        PMID: 28702828     DOI: 10.1007/s11845-017-1652-6

Source DB:  PubMed          Journal:  Ir J Med Sci        ISSN: 0021-1265            Impact factor:   1.568


  18 in total

1.  Laparoscopic radical nephrectomy in 100 patients: a single center experience from the United States.

Authors:  I S Gill; A M Meraney; D K Schweizer; S S Savage; M G Hobart; G T Sung; D Nelson; A C Novick
Journal:  Cancer       Date:  2001-10-01       Impact factor: 6.860

2.  Laparoscopic nephrectomy. 1991.

Authors:  Ralph V Clayman; Louis R Kavoussi; Nathaniel J Soper; Stephen M Dierks; Shimon Meretyk; Michael D Darcy; Stephanie R Long; Frederick D Roemer; Edward D Pingleton; Paul G Thomson
Journal:  J Urol       Date:  2002-02       Impact factor: 7.450

3.  The long-term outcome of laparoscopic radical nephrectomy for small renal cell carcinoma.

Authors:  Y Ono; T Kinukawa; R Hattori; M Gotoh; O Kamihira; S Ohshima
Journal:  J Urol       Date:  2001-06       Impact factor: 7.450

4.  Laparoscopic versus open radical nephrectomy for large renal tumors: a long-term prospective comparison.

Authors:  A K Hemal; A Kumar; R Kumar; P Wadhwa; A Seth; N P Gupta
Journal:  J Urol       Date:  2007-03       Impact factor: 7.450

Review 5.  EAU guidelines on renal cell carcinoma: 2014 update.

Authors:  Borje Ljungberg; Karim Bensalah; Steven Canfield; Saeed Dabestani; Fabian Hofmann; Milan Hora; Markus A Kuczyk; Thomas Lam; Lorenzo Marconi; Axel S Merseburger; Peter Mulders; Thomas Powles; Michael Staehler; Alessandro Volpe; Axel Bex
Journal:  Eur Urol       Date:  2015-01-21       Impact factor: 20.096

6.  Survival of patients with nonmetastatic pT3 renal tumours: a matched comparison of laparoscopic vs open radical nephrectomy.

Authors:  Karim Bensalah; Laurent Salomon; Herve Lang; Laurent Zini; Didier Jacqmin; Andrea Manunta; Maxime Crepel; Vincenzo Ficarra; Luca Cindolo; Alexandre de La Taille; Pierre Karakiewicz; Jean-Jacques Patard
Journal:  BJU Int       Date:  2009-07-16       Impact factor: 5.588

7.  Laparoscopic radical nephrectomy for patients with pathologic T3b renal-cell carcinoma: the Johns Hopkins experience.

Authors:  Thomas J Guzzo; Edward M Schaeffer; Brian K McNeil; Richard A Pollock; Christian P Pavlovich; Mohamad E Allaf
Journal:  J Endourol       Date:  2009-01       Impact factor: 2.942

8.  Seven years after laparoscopic radical nephrectomy: oncologic and renal functional outcomes.

Authors:  Jose R Colombo; Georges-Pascal Haber; John E Jelovsek; Brian Lane; Andrew C Novick; Inderbir S Gill
Journal:  Urology       Date:  2008-03-03       Impact factor: 2.649

9.  Laparoscopic lymph node dissection in clinically node-negative patients undergoing laparoscopic nephrectomy for renal carcinoma.

Authors:  Terence N Chapman; Satish Sharma; Shaozeng Zhang; Michael K Wong; Hyung L Kim
Journal:  Urology       Date:  2008-02       Impact factor: 2.649

10.  Matched pair analysis of laparoscopic versus open radical nephrectomy for the treatment of T3 renal cell carcinoma.

Authors:  A Laird; K C C Choy; H Delaney; M L Cutress; K M O'Connor; D A Tolley; S A McNeill; G D Stewart; A C P Riddick
Journal:  World J Urol       Date:  2014-03-20       Impact factor: 4.226

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  1 in total

1.  Comparison of Laparoscopy and Open Radical Nephrectomy of Renal Cell Cancer.

Authors:  Dong Wang; Zejun Xiao; Jianzhong Shou; Changling Li; Nianzeng Xing
Journal:  Open Med (Wars)       Date:  2019-05-17
  1 in total

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