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Literature DB >> 287020

Induction of rat sarcomas in rats treated with antithymocyte sera after transplantation of human cancer cells.

R J Huebner, D C Fish, D Djurickovic, R W Trimmer, A L Bare, R M Bare, G T Smith.

Abstract

Human cancer cells that had had high (greater than 160) tissue culture passages, when transplanted into antithymocyte-treated F344 newborn rats, caused induction of rat sarcomas in the rats within 2 or 3 subcultures, whereas human cancer cells with low (5-33) passages in vitro did not cause overt induction of rat sarcomas until after 5-10 subtransplantations. Because oncornavirus activity was not detected in either rat or human tumors, it is suggested that transforming sequences located on the human tumor cells may have been transferred to supporting rat reticulum cells in close contact with the human cancer cells.

Entities: Disease Species

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Year: 1979 PMID： 287020 PMCID： PMC383477 DOI： 10.1073/pnas.76.4.1793

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

4 in total

1. In vitro isolation of stable rat sarcoma viruses.

Authors: S Rasheed; M B Gardner; R J Huebner
Journal: Proc Natl Acad Sci U S A Date: 1978-06 Impact factor: 11.205

2. Cultivation in vitro of cells derived from a human rhabdomyosarcoma.

Authors: R M McAllister; J Melnyk; J Z Finkelstein; E C Adams; M B Gardner
Journal: Cancer Date: 1969-09 Impact factor: 6.860

3. Cultivation in vitro of cells derived from a human osteosarcoma.

Authors: R M McAllister; M B Gardner; A E Greene; C Bradt; W W Nichols; B H Landing
Journal: Cancer Date: 1971-02 Impact factor: 6.860

4. Characterization of human cells transformed in vitro by N-methyl-N'-nitro-N-nitrosoguanidine.

Authors: J S Rhim; D L Putman; P Arnstein; R J Huebner; R M McAllister
Journal: Int J Cancer Date: 1977-04-15 Impact factor: 7.396

4 in total

8 in total

Review 8. Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research.

Authors: Shengming Zhu; Jiangang Wang; Lucas Zellmer; Ningzhi Xu; Mei Liu; Yun Hu; Hong Ma; Fei Deng; Wenxiu Yang; Dezhong Joshua Liao
Journal: J Cancer Date: 2022-07-04 Impact factor: 4.478

8 in total

Induction of rat sarcomas in rats treated with antithymocyte sera after transplantation of human cancer cells.

1. In vitro isolation of stable rat sarcoma viruses.

2. Cultivation in vitro of cells derived from a human rhabdomyosarcoma.

3. Cultivation in vitro of cells derived from a human osteosarcoma.

4. Characterization of human cells transformed in vitro by N-methyl-N'-nitro-N-nitrosoguanidine.

1. Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells.

2. In vivo horizontal oncogenesis by a human tumor in nude mice.

3. Induction of sarcomas in athymic mice.

4. In vivo induction of neoplastic growth in nude mouse connective tissue adjacent to xenografted human tumors.

5. Enhanced tumorigenicity of cloned UV-regressor tumor lines following selected in vivo and in vitro manipulations.

6. In-vivo fusion of human cancer and hamster stromal cells permanently transduces and transcribes human DNA.

7. Alterations of mouse proto-oncogenes in sarcomas induced after transplantation of human tumors in athymic nude mice.

Review 8. Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research.