| Literature DB >> 28699650 |
Eli Muchtar1, Angela Dispenzieri1, Martha Q Lacy1, Francis K Buadi1, Prashant Kapoor1, Suzanne R Hayman1, Wilson Gonsalves1, Rahma Warsame1, Taxiarchis V Kourelis1, Rajshekhar Chakraborty1,2, Stephen Russell1, John A Lust1, Yi Lin1, Ronald S Go1, Steven Zeldenrust1, David Dingli1, Nelson Leung1,3, S Vincent Rajkumar1, Robert A Kyle1, Shaji K Kumar1, Morie A Gertz1.
Abstract
The significance of serum lactate dehydrogenase (LDH) in light chain (AL) amyloidosis has not been previously explored. We studied 1019 newly diagnosed patients and correlated the elevation of LDH above the upper limit of normal (ULN) with disease characteristics and outcome. Four hundred and nine patients had an LDH above ULN, representing 40% of the study population. Patients with an elevated LDH were older, were less likely to be male and had more extensive organ involvement compared to patients with a normal LDH. Patients with high LDH had greater cardiac and renal dysfunction. Elevated LDH was an independent prognostic marker for overall survival and for death within 6 months of diagnosis, but this was restricted to patients not eligible for stem cell transplant. Serum LDH may act as a marker for organ damage and should be explored as a potential marker for tissue healing and organ recovery.Entities:
Keywords: damage; early death; lactate dehydrogenase; prognosis; tissue
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Year: 2017 PMID： 28699650 PMCID： PMC5591068 DOI： 10.1111/bjh.14830
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998