Elena García-Martín1,2,3, Carmen Martínez2,4, Mercedes Serrador5, Hortensia Alonso-Navarro6,7, Francisco Navacerrada6,8, Gara Esguevillas1, Esteban García-Albea7, José A G Agúndez1,2,3, Félix Javier Jiménez-Jiménez6,7. 1. Department of Pharmacology, University of Extremadura, Cáceres, Spain. 2. Red de Investigación de reacciones adversas a alergenos y fármacos, Instituto de Salud Carlos III, Madrid, Spain. 3. AMGenomics, Edificio Tajo, Avda. de la Universidad s/n, Cáceres, Spain. 4. Department of Pharmacology, University of Extremadura, Badajoz, Spain. 5. Department of Family Medicine, Hospital "Príncipe de Asturias,", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain. 6. Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain. 7. Department of Medicine-Neurology, Hospital "Príncipe de Asturias," Universidad de Alcalá, Alcalá de Henares, Madrid, Spain. 8. Service of Neurology, Hospital "Ramón y Cajal,", Universidad de Alcalá, Madrid, Spain.
Abstract
BACKGROUND/ OBJECTIVES: The possible role of gammaaminobutyric acid (GABA) in the pathogenesis of migraine has been suggested by a number of biochemical, pharmacological, neurophysiological and experimental data. We investigated the possible association between the most common single nucleotide polymorphisms (SNPs) in the GABA receptor rho1, 2, and 3 genes (GABRR1, GABRR2, and GABRR3) and the risk of developing migraine. METHODS: The frequency of GABRR1 rs12200969, GABRR1 rs1186902, GABRR2 rs282129, and GABRR3 rs832032 genotypes and allelic variants were studied in a case-control association study involving 197 patients with migraine and 278 healthy controls by means of a TaqMan-based qPCR Assay. We also studied the possible influence of gender, age at onset of migraine, positive family history of migraine, presence or absence of aura, and triggering of migraine by ethanol on the frequency of the genotypes. RESULTS: The frequencies of the genotypes and allelic variants of the 4 SNPs were similar in migraine patients and controls. Gender, positive family history of migraine, presence or absence of aura, and triggering of migraine attacks by ethanol did not influence the frequency of these genotypes. Carriers of the minor allele of the rs1186902 SNP showed a trend towards later onset of migraine. CONCLUSION: The most common polymorphisms in the GABRR genes seemed to be not associated with the risk for migraine in Caucasian Spanish people, although one of them (GABRR1 rs1186902) shows a statistically significant association with the age of onset of migraine.
BACKGROUND/ OBJECTIVES: The possible role of gammaaminobutyric acid (GABA) in the pathogenesis of migraine has been suggested by a number of biochemical, pharmacological, neurophysiological and experimental data. We investigated the possible association between the most common single nucleotide polymorphisms (SNPs) in the GABA receptor rho1, 2, and 3 genes (GABRR1, GABRR2, and GABRR3) and the risk of developing migraine. METHODS: The frequency of GABRR1rs12200969, GABRR1rs1186902, GABRR2rs282129, and GABRR3rs832032 genotypes and allelic variants were studied in a case-control association study involving 197 patients with migraine and 278 healthy controls by means of a TaqMan-based qPCR Assay. We also studied the possible influence of gender, age at onset of migraine, positive family history of migraine, presence or absence of aura, and triggering of migraine by ethanol on the frequency of the genotypes. RESULTS: The frequencies of the genotypes and allelic variants of the 4 SNPs were similar in migrainepatients and controls. Gender, positive family history of migraine, presence or absence of aura, and triggering of migraine attacks by ethanol did not influence the frequency of these genotypes. Carriers of the minor allele of the rs1186902 SNP showed a trend towards later onset of migraine. CONCLUSION: The most common polymorphisms in the GABRR genes seemed to be not associated with the risk for migraine in Caucasian Spanish people, although one of them (GABRR1rs1186902) shows a statistically significant association with the age of onset of migraine.
Authors: Elena García-Martín; Gara Esguevillas; Mercedes Serrador; Hortensia Alonso-Navarro; Francisco Navacerrada; Gemma Amo; Esteban García-Albea; José A G Agúndez; Félix Javier Jiménez-Jiménez Journal: J Neural Transm (Vienna) Date: 2018-01-03 Impact factor: 3.575
Authors: Elena García-Martín; Santiago Navarro-Muñoz; Christopher Rodriguez; Mercedes Serrador; Hortensia Alonso-Navarro; Marisol Calleja; Laura Turpín-Fenoll; Marta Recio-Bermejo; Rafael García-Ruiz; Jorge Millán-Pascual; Francisco Navacerrada; José Francisco Plaza-Nieto; Esteban García-Albea; José A G Agúndez; Félix Javier Jiménez-Jiménez Journal: Pharmacogenomics J Date: 2019-12-03 Impact factor: 3.550
Authors: Elena García-Martín; María I Ramos; José A Cornejo-García; Segismundo Galván; James R Perkins; Laura Rodríguez-Santos; Hortensia Alonso-Navarro; Félix J Jiménez-Jiménez; José A G Agúndez Journal: Front Cell Neurosci Date: 2018-01-31 Impact factor: 5.505