Literature DB >> 28699057

The Role of Lipid Bodies in the Microglial Aging Process and Related Diseases.

Xirong Hu1,2, Benhong Xu3,4, Wei Ge5,6.   

Abstract

Lipid bodies (LBs) have long been considered to be organelles merely for the storage of neutral lipids. However, recent studies have shown the significance of LBs in signal transduction, especially in glial cells, including microglia. Microglial cells are the resident mononuclear phagocytes in the central nervous system and have a close relationship with the aging process and neurodegenerative diseases. Evidence suggests that LBs accumulate and are remodeled during the aging process and the development of neuroinflammatory conditions. However, the mechanisms underlying the formation of LBs under these conditions and the mechanism by which LB remodeling influences the progression of neurodegeneration remain to be clarified. In this review, we have summarized the findings from recent studies with the aim of further elucidating these issues.

Entities:  

Keywords:  Lipid bodies; Microglia; Neurodegeneration

Mesh：

Year:  2017        PMID： 28699057     DOI： 10.1007/s11064-017-2351-4

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  82 in total

1.  Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia.

Authors:  Armen Khatchadourian; Simon D Bourque; Vincent R Richard; Vladimir I Titorenko; Dusica Maysinger
Journal:  Biochim Biophys Acta       Date:  2012-01-28

Review 2.  Physiology of microglia.

Authors:  Helmut Kettenmann; Uwe-Karsten Hanisch; Mami Noda; Alexei Verkhratsky
Journal:  Physiol Rev       Date:  2011-04       Impact factor: 37.312

Review 3.  Lipofuscin of the retinal pigment epithelium: a review.

Authors:  C J Kennedy; P E Rakoczy; I J Constable
Journal:  Eye (Lond)       Date:  1995       Impact factor: 3.775

4.  Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity.

Authors:  Albert Herms; Marta Bosch; Nicholas Ariotti; Babu J N Reddy; Alba Fajardo; Andrea Fernández-Vidal; Anna Alvarez-Guaita; Manuel Alejandro Fernández-Rojo; Carles Rentero; Francesc Tebar; Carlos Enrich; María-Isabel Geli; Robert G Parton; Steven P Gross; Albert Pol
Journal:  Curr Biol       Date:  2013-07-18       Impact factor: 10.834

5.  The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology.

Authors:  Kimberly M Szymanski; Derk Binns; René Bartz; Nick V Grishin; Wei-Ping Li; Anil K Agarwal; Abhimanyu Garg; Richard G W Anderson; Joel M Goodman
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-18       Impact factor: 11.205

Review 6.  A role for lipid droplets in inter-membrane lipid traffic.

Authors:  John K Zehmer; Youguo Huang; Gong Peng; Jing Pu; Richard G W Anderson; Pingsheng Liu
Journal:  Proteomics       Date:  2009-02       Impact factor: 3.984

7.  Glial β-oxidation regulates Drosophila energy metabolism.

Authors:  Joachim G Schulz; Antonio Laranjeira; Leen Van Huffel; Annette Gärtner; Sven Vilain; Jarl Bastianen; Paul P Van Veldhoven; Carlos G Dotti
Journal:  Sci Rep       Date:  2015-01-15       Impact factor: 4.379

Review 8.  Docosahexaenoic acid and adult memory: a systematic review and meta-analysis.

Authors:  Karin Yurko-Mauro; Dominik D Alexander; Mary E Van Elswyk
Journal:  PLoS One       Date:  2015-03-18       Impact factor: 3.240

9.  Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis.

Authors:  Amanda Sierra; Oihane Abiega; Anahita Shahraz; Harald Neumann
Journal:  Front Cell Neurosci       Date:  2013-01-30       Impact factor: 5.505

10.  Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells.

Authors:  Marie-Eve Tremblay; Issan Zhang; Kanchan Bisht; Julie C Savage; Cynthia Lecours; Martin Parent; Vladimir Titorenko; Dusica Maysinger
Journal:  J Neuroinflammation       Date:  2016-05-24       Impact factor: 8.322
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  3 in total

1.  Microglia-Derived Adiposomes are Potential Targets for the Treatment of Ischemic Stroke.

Authors:  Chi-Hsin Lin; Li-Ya Liao; Tsung-Ying Yang; Yi-Jyun Chang; Chia-Wen Tung; Shih-Lan Hsu; Chi-Mei Hsueh
Journal:  Cell Mol Neurobiol       Date:  2019-03-09       Impact factor: 5.046

2.  Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids.

Authors:  Jing Zhao; Wenyan Lu; Yingxue Ren; Yuan Fu; Yuka A Martens; Francis Shue; Mary D Davis; Xue Wang; Kai Chen; Fuyao Li; Chia-Chen Liu; Neill R Graff-Radford; Zbigniew K Wszolek; Steven G Younkin; David A Brafman; Nilüfer Ertekin-Taner; Yan W Asmann; Dennis W Dickson; Ziying Xu; Meixia Pan; Xianlin Han; Takahisa Kanekiyo; Guojun Bu
Journal:  Acta Neuropathol       Date:  2021-08-28       Impact factor: 15.887

3.  Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

Authors:  Julia Marschallinger; Tal Iram; Macy Zardeneta; Song E Lee; Benoit Lehallier; Michael S Haney; John V Pluvinage; Vidhu Mathur; Oliver Hahn; David W Morgens; Justin Kim; Julia Tevini; Thomas K Felder; Heimo Wolinski; Carolyn R Bertozzi; Michael C Bassik; Ludwig Aigner; Tony Wyss-Coray
Journal:  Nat Neurosci       Date:  2020-01-20       Impact factor: 24.884
  3 in total

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