Mayte Martinez-Herrera1,2, Francisco Javier Silvestre1,2, Javier Silvestre-Rangil2, Celia Bañuls3,4, Milagros Rocha3,5, Antonio Hernández-Mijares3,4,6. 1. Service of Stomatology, University Hospital Doctor Peset-FISABIO, Valencia, Spain. 2. Department of Stomatology, University of Valencia, Valencia, Spain. 3. Service of Endocrinology and Nutrition, University Hospital Doctor Peset-FISABIO, Valencia, Spain. 4. Institute of Health Research INCLIVA, University of Valencia, Valencia, Spain. 5. CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Valencia, Spain. 6. Department of Medicine, University of Valencia, Valencia, Spain.
Abstract
AIM: We explored the association between obesity and periodontitis with the aim of determining the possible role of insulin resistance (IR) in this relationship. MATERIALS AND METHODS: A total of 212 subjects-110 obese and 102 lean individuals-were evaluated for periodontal disease and divided according to IR: a lean group without IR (LWIR), an obese group without IR (OWIR), and an obese group with IR (OIR). Anthropometric, metabolic, inflammatory and periodontal parameters were evaluated. RESULTS: Periodontitis was more prevalent in obese (80.9%) than in lean subjects (41.2%), with the former group showing a risk of periodontitis sixfold that of the latter. Obese subjects as a whole displayed higher diastolic blood pressure, TNFα and hsCRP and lower HDL cholesterol than lean subjects. OIR had higher systolic blood pressure, glucose, insulin, HOMA-IR, A1c, triglycerides and number of teeth with PD ≥ 4 mm than OWIR, while other periodontal variables remained unaltered. The multivariable regression model showed that probing depth, bleeding on probing and HOMA-IR were independent predictors of number of teeth with PD ≥ 4 mm. CONCLUSION: Our data support an association between obesity and periodontitis, and point to a central role of IR. Periodontitis tends to be more extensive in obese patients with IR.
AIM: We explored the association between obesity and periodontitis with the aim of determining the possible role of insulin resistance (IR) in this relationship. MATERIALS AND METHODS: A total of 212 subjects-110 obese and 102 lean individuals-were evaluated for periodontal disease and divided according to IR: a lean group without IR (LWIR), an obese group without IR (OWIR), and an obese group with IR (OIR). Anthropometric, metabolic, inflammatory and periodontal parameters were evaluated. RESULTS:Periodontitis was more prevalent in obese (80.9%) than in lean subjects (41.2%), with the former group showing a risk of periodontitis sixfold that of the latter. Obese subjects as a whole displayed higher diastolic blood pressure, TNFα and hsCRP and lower HDL cholesterol than lean subjects. OIR had higher systolic blood pressure, glucose, insulin, HOMA-IR, A1c, triglycerides and number of teeth with PD ≥ 4 mm than OWIR, while other periodontal variables remained unaltered. The multivariable regression model showed that probing depth, bleeding on probing and HOMA-IR were independent predictors of number of teeth with PD ≥ 4 mm. CONCLUSION: Our data support an association between obesity and periodontitis, and point to a central role of IR. Periodontitis tends to be more extensive in obesepatients with IR.
Authors: Cecilia Fabiana Márquez-Arrico; Javier Silvestre-Rangil; Laura Gutiérrez-Castillo; Mayte Martinez-Herrera; Francisco Javier Silvestre; Milagros Rocha Journal: J Clin Med Date: 2020-05-23 Impact factor: 4.241