Literature DB >> 28696240

Biofilms Formed by Isolates from Recurrent Vulvovaginal Candidiasis Patients Are Heterogeneous and Insensitive to Fluconazole.

Leighann Sherry1, Ryan Kean1,2, Emily McKloud1, Lindsay E O'Donnell1, Rebecca Metcalfe3, Brian L Jones4, Gordon Ramage5.   

Abstract

Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm-forming capacity, which is associated with altered antifungal drug sensitivity.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Candida; biofilm; fluconazole; vulvovaginal candidiasis

Mesh:

Substances:

Year:  2017        PMID: 28696240      PMCID: PMC5571368          DOI: 10.1128/AAC.01065-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


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