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Literature DB >> 28696230

Implications of Antimicrobial Combinations in Complex Wound Biofilms Containing Fungi.

Eleanor M Townsend^1,2, Leighann Sherry^1,2, Ryan Kean¹, Donald Hansom¹, William G Mackay², Craig Williams², John Butcher², Gordon Ramage³.

Abstract

Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches influenced biofilm composition, this had no discernible effect on overall quantity. Only by combining bacterium- and fungus-specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.

Entities: Disease

Keywords: Candida; antimicrobial; biofilm; chronic wound; polymicrobial

Mesh：

Substances：

Year: 2017 PMID： 28696230 PMCID： PMC5571281 DOI： 10.1128/AAC.00672-17

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

19 in total

1. The estimation of the bactericidal power of the blood.

Authors: A A Miles; S S Misra; J O Irwin
Journal: J Hyg (Lond) Date: 1938-11

2. Targeted treatment of invasive fungal infections accelerates healing of foot wounds in patients with Type 2 diabetes.

Authors: G Chellan; K Neethu; A K Varma; T S Mangalanandan; S Shashikala; K R Dinesh; K R Sundaram; N Varma; R V Jayakumar; A Bal; H Kumar
Journal: Diabet Med Date: 2012-09 Impact factor: 4.359

3. Risk factors for recurrence of diabetic foot ulcers: prospective follow-up analysis in the Eurodiale subgroup.

Authors: Michal Dubský; Alexandra Jirkovská; Robert Bem; Vladimira Fejfarová; Jelena Skibová; Nicolaas C Schaper; Benjamin A Lipsky
Journal: Int Wound J Date: 2012-06-19 Impact factor: 3.315

4. Quantitative real-time PCR combined with propidium monoazide for the selective quantification of viable periodontal pathogens in an in vitro subgingival biofilm model.

Authors: M C Sánchez; M J Marín; E Figuero; A Llama-Palacios; R León; V Blanc; D Herrera; M Sanz
Journal: J Periodontal Res Date: 2013-04-15 Impact factor: 4.419

5. Analysis of viable vs. dead Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis using selective quantitative real-time PCR with propidium monoazide.

Authors: M C Sánchez; M J Marín; E Figuero; A Llama-Palacios; D Herrera; M Sanz
Journal: J Periodontal Res Date: 2012-09-07 Impact factor: 4.419

6. Biofilms in chronic diabetic foot ulcers--a study of 2 cases.

Authors: Daniëlle Neut; Elvira J A Tijdens-Creusen; Sjoerd K Bulstra; Henny C van der Mei; Henk J Busscher
Journal: Acta Orthop Date: 2011-05-11 Impact factor: 3.717

7. Commensal Protection of Staphylococcus aureus against Antimicrobials by Candida albicans Biofilm Matrix.

Authors: Eric F Kong; Christina Tsui; Sona Kucharíková; David Andes; Patrick Van Dijck; Mary Ann Jabra-Rizk
Journal: MBio Date: 2016-10-11 Impact factor: 7.867

8. Candida albicans Mycofilms Support Staphylococcus aureus Colonization and Enhances Miconazole Resistance in Dual-Species Interactions.

Authors: Ryan Kean; Ranjith Rajendran; Jennifer Haggarty; Eleanor M Townsend; Bryn Short; Karl E Burgess; Sue Lang; Owain Millington; William G Mackay; Craig Williams; Gordon Ramage
Journal: Front Microbiol Date: 2017-02-23 Impact factor: 5.640

9. Redefining the Chronic-Wound Microbiome: Fungal Communities Are Prevalent, Dynamic, and Associated with Delayed Healing.

Authors: Lindsay Kalan; Michael Loesche; Brendan P Hodkinson; Kristopher Heilmann; Gordon Ruthel; Sue E Gardner; Elizabeth A Grice
Journal: MBio Date: 2016-09-06 Impact factor: 7.867

10. Method to quantify live and dead cells in multi-species oral biofilm by real-time PCR with propidium monoazide.

Authors: Gerard Alvarez; Marta González; Sergio Isabal; Vanessa Blanc; Rubén León
Journal: AMB Express Date: 2013-01-04 Impact factor: 3.298

11 in total

Review 1. Fungi in the Wound Microbiome.

Authors: Lindsay Kalan; Elizabeth A Grice
Journal: Adv Wound Care (New Rochelle) Date: 2018-07-01 Impact factor: 4.730

2. Hydrogen Peroxide-Generating Electrochemical Scaffold Activity against Trispecies Biofilms.

Authors: Yash S Raval; Abdelrhman Mohamed; James Song; Kerryl E Greenwood-Quaintance; Haluk Beyenal; Robin Patel
Journal: Antimicrob Agents Chemother Date: 2020-03-24 Impact factor: 5.191

3. Farnesol delivery via polymeric nanoparticle carriers inhibits cariogenic cross-kingdom biofilms and prevents enamel demineralization.

Authors: Tatsuro Ito; Kenneth R Sims; Yuan Liu; Zhenting Xiang; Rodrigo A Arthur; Anderson T Hara; Hyun Koo; Danielle S W Benoit; Marlise I Klein
Journal: Mol Oral Microbiol Date: 2022-08-04 Impact factor: 4.107

Implications of Antimicrobial Combinations in Complex Wound Biofilms Containing Fungi.

1. The estimation of the bactericidal power of the blood.

2. Targeted treatment of invasive fungal infections accelerates healing of foot wounds in patients with Type 2 diabetes.

3. Risk factors for recurrence of diabetic foot ulcers: prospective follow-up analysis in the Eurodiale subgroup.

4. Quantitative real-time PCR combined with propidium monoazide for the selective quantification of viable periodontal pathogens in an in vitro subgingival biofilm model.

5. Analysis of viable vs. dead Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis using selective quantitative real-time PCR with propidium monoazide.

6. Biofilms in chronic diabetic foot ulcers--a study of 2 cases.

7. Commensal Protection of Staphylococcus aureus against Antimicrobials by Candida albicans Biofilm Matrix.

8. Candida albicans Mycofilms Support Staphylococcus aureus Colonization and Enhances Miconazole Resistance in Dual-Species Interactions.

9. Redefining the Chronic-Wound Microbiome: Fungal Communities Are Prevalent, Dynamic, and Associated with Delayed Healing.

10. Method to quantify live and dead cells in multi-species oral biofilm by real-time PCR with propidium monoazide.

Review 1. Fungi in the Wound Microbiome.

2. Hydrogen Peroxide-Generating Electrochemical Scaffold Activity against Trispecies Biofilms.

3. Farnesol delivery via polymeric nanoparticle carriers inhibits cariogenic cross-kingdom biofilms and prevents enamel demineralization.

4. In Vitro Antibiofilm Activity of Hydrogen Peroxide-Generating Electrochemical Bandage against Yeast Biofilms.

5. Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm.

6. Assessing the inflammatory response to in vitro polymicrobial wound biofilms in a skin epidermis model.

7. Priority effects dictate community structure and alter virulence of fungal-bacterial biofilms.

Review 8. Gaining Insights from Candida Biofilm Heterogeneity: One Size Does Not Fit All.

Review 9. How Biofilm Growth Affects Candida-Host Interactions.

10. Hydrogen-peroxide generating electrochemical bandage is active in vitro against mono- and dual-species biofilms.