Ashutosh Gupta1,2, Arvind Tripathi3, Piyush Sharma4. 1. Department of Prosthodontics, Dental College, Azamgarh, India. drashutosh.gupta@yahoo.co.in. 2. , 5/62, Vikas Khand, Gomti Nagar, Lucknow, 226010, India. drashutosh.gupta@yahoo.co.in. 3. Saraswati Dental College and Hospital, Lucknow, India. 4. Department of Orthodontics, Dental College, Azamgarh, India.
Abstract
BACKGROUND: Obstructive sleep apnea (OSA) manifests as a reduction or complete cessation of airflow despite an ongoing inspiratory effort, leading to hypoxemia and hypercapnia. The inability to maintain normal breathing reduces the oxygen saturation in blood leading to a cycle of various systemic implications. Hence, a prospective single arm study was planned to evaluate the long-term (2 years) effect of oral appliance on cardiovascular fitness and psychomotor performance in patients with mild to moderate obstructive sleep apnea. METHODS: Thirty dentulous OSA patients (25 males; 5 females; age 41 ± 4 years; BMI 22 ± 5; AHI 5-30) were included in the study. All the patients were assessed for systolic blood pressure (SBP), diastolic blood pressure (DBP), apnea/hypopnea index (AHI), lipid peroxidation, and psychomotor vigilance test at baseline, 6 months, 1 year, and 2 years after wearing mandibular advancement splint (MAS). RESULTS: A significant reduction in AHI, blood pressure, and lipid peroxidation was observed following MAS use. Psychomotor vigilance test showed marked improvement in response time with almost 0 count of lapses after 2 years of MAS use. CONCLUSIONS: The present study suggested that MAS can be helpful in improving cardiovascular fitness and cognitive response in patients with mild to moderate OSA.
BACKGROUND:Obstructive sleep apnea (OSA) manifests as a reduction or complete cessation of airflow despite an ongoing inspiratory effort, leading to hypoxemia and hypercapnia. The inability to maintain normal breathing reduces the oxygen saturation in blood leading to a cycle of various systemic implications. Hence, a prospective single arm study was planned to evaluate the long-term (2 years) effect of oral appliance on cardiovascular fitness and psychomotor performance in patients with mild to moderate obstructive sleep apnea. METHODS: Thirty dentulous OSA patients (25 males; 5 females; age 41 ± 4 years; BMI 22 ± 5; AHI 5-30) were included in the study. All the patients were assessed for systolic blood pressure (SBP), diastolic blood pressure (DBP), apnea/hypopnea index (AHI), lipid peroxidation, and psychomotor vigilance test at baseline, 6 months, 1 year, and 2 years after wearing mandibular advancement splint (MAS). RESULTS: A significant reduction in AHI, blood pressure, and lipid peroxidation was observed following MAS use. Psychomotor vigilance test showed marked improvement in response time with almost 0 count of lapses after 2 years of MAS use. CONCLUSIONS: The present study suggested that MAS can be helpful in improving cardiovascular fitness and cognitive response in patients with mild to moderate OSA.
Entities:
Keywords:
Apnea/hypopnea index (AHI); Mandibular advancement splint; Obstructive sleep apnea; Oxidative stress; Psychomotor vigilance test
Authors: Yüksel Peker; Jan Hedner; Jeanette Norum; Holger Kraiczi; Jan Carlson Journal: Am J Respir Crit Care Med Date: 2002-07-15 Impact factor: 21.405
Authors: Olivier M Vanderveken; An Boudewyns; Quan Ni; Bhavani Kashyap; Johan Verbraecken; Wilfried De Backer; Paul Van de Heyning Journal: J Cardiovasc Transl Res Date: 2010-11-20 Impact factor: 4.132
Authors: Winfried Randerath; Jan de Lange; Jan Hedner; Jean Pierre T F Ho; Marie Marklund; Sofia Schiza; Jörg Steier; Johan Verbraecken Journal: ERJ Open Res Date: 2022-06-27