S Bodea1. 1. Clinic for Diagnostic and Interventional Neuroradiology, Saarland University Medical Center, Kirrberger Strasse, Gebäude 90, 66421, Homburg/Saar, Germany. silviu-vasile.bodea@uks.eu.
Abstract
BACKGROUND: High-risk drug consumption is a matter of great concern for public health actors in industrialised countries. The latest trends show a market tendency towards diversification and increasing demand for high-purity synthetic drugs. While most consumers seek medical help after cannabis use, it is high-risk drugs like cocaine, heroin and amphetamines that account for most of the 1000 drug-related deaths that occur in Germany every year. PURPOSE: This article presents the most prominent in vivo cerebral metabolic information in cocaine, heroin and methamphetamine users provided by MRI spectroscopy and PET imaging. MATERIALS AND METHODS: We reviewed the literature reporting neuroimaging studies of in vivo metabolic data for methamphetamine, cocaine and heroin consumption published up to March 2017. The search was conducted using PubMed and a combination of the following key words: methamphetamine, cocaine, heroin, MR spectroscopy, PET. CONCLUSION: MRI and PET are indispensable tools in gauging brain metabolic response to illegal drug abuse. Future breakthroughs in this field will most likely come from the investigation of novel neurotransmitter systems in PET and imaging phosphorus and carbon metabolites in MRI.
BACKGROUND: High-risk drug consumption is a matter of great concern for public health actors in industrialised countries. The latest trends show a market tendency towards diversification and increasing demand for high-purity synthetic drugs. While most consumers seek medical help after cannabis use, it is high-risk drugs like cocaine, heroin and amphetamines that account for most of the 1000 drug-related deaths that occur in Germany every year. PURPOSE: This article presents the most prominent in vivo cerebral metabolic information in cocaine, heroin and methamphetamine users provided by MRI spectroscopy and PET imaging. MATERIALS AND METHODS: We reviewed the literature reporting neuroimaging studies of in vivo metabolic data for methamphetamine, cocaine and heroin consumption published up to March 2017. The search was conducted using PubMed and a combination of the following key words: methamphetamine, cocaine, heroin, MR spectroscopy, PET. CONCLUSION: MRI and PET are indispensable tools in gauging brain metabolic response to illegal drug abuse. Future breakthroughs in this field will most likely come from the investigation of novel neurotransmitter systems in PET and imaging phosphorus and carbon metabolites in MRI.
Authors: Lea M Hulka; Milan Scheidegger; Matthias Vonmoos; Katrin H Preller; Markus R Baumgartner; Marcus Herdener; Erich Seifritz; Anke Henning; Boris B Quednow Journal: Addict Biol Date: 2014-12-30 Impact factor: 4.280
Authors: Fleur M Howells; Anne Uhlmann; Henk Temmingh; Heidi Sinclair; Ernesta Meintjes; Don Wilson; Dan J Stein Journal: Schizophr Res Date: 2014-02-12 Impact factor: 4.939
Authors: Shaolin Yang; Betty Jo Salmeron; Thomas J Ross; Zheng-Xiong Xi; Elliot A Stein; Yihong Yang Journal: Psychiatry Res Date: 2009-11-10 Impact factor: 3.222
Authors: Patrick D Worhunsky; David Matuskey; Jean-Dominique Gallezot; Edward C Gaiser; Nabeel Nabulsi; Gustavo A Angarita; Vince D Calhoun; Robert T Malison; Marc N Potenza; Richard E Carson Journal: Neuroimage Date: 2017-01-19 Impact factor: 6.556