Effects of hallucinogenic drugs on serotonergic neuronal systems.

Studies indicate that hallucinogens markedly suppress the discharge of serotonin containing neurons in the dorsal raphe nucleus. Forebrain neurons receiving a major serotonergic input are relatively insensitive to hallucinogens. These actions of hallucinogens are not sufficient to explain the psychoactive effects of these drugs. Evidence is presented to indicate that hallucinogens sensitize serotonin and norepinephrine receptors in the facial nucleus. This receptor sensitizing effect is common to all, and specific for, hallucinogens. It is suggested that a mechanism of receptor sensitization might account for the altered perceptual reactivity produced by hallucinogens.