Literature DB >> 28694231

Repurposing Ivacaftor for treatment of Staphylococcus aureus infections.

Ritesh Thakare1, Alok Kumar Singh1, Swetarka Das1, N Vasudevan2, Gorakhnath R Jachak2, D Srinivasa Reddy2, Arunava Dasgupta1, Sidharth Chopra3.   

Abstract

Drug repurposing of non-antimicrobials is a novel method to augment a seriously depleted drug pipeline for targeting drug-resistant pathogens. This article highlights the potent antimicrobial activity of Ivacaftor against Staphylococcus aureus, including vancomycin- and other multidrug-resistant strains. The potent activity of Ivacaftor in vivo is also demonstrated in a murine neutropenic thigh infection model. Taken together, these results support the potential of Ivacaftor as an antimicrobial agent for the treatment of staphylococcal infections.
Copyright © 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Entities:  

Keywords:  Antibiotics; Drug-repurposing; Ivacaftor; MRSA

Mesh：

Substances：

Year:  2017        PMID： 28694231     DOI： 10.1016/j.ijantimicag.2017.03.020

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  5 in total

1.  The Rapid Reduction of Infection-Related Visits and Antibiotic Use Among People With Cystic Fibrosis After Starting Elexacaftor-Tezacaftor-Ivacaftor.

Authors:  Aaron C Miller; Logan M Harris; Joseph E Cavanaugh; Mahmoud Abou Alaiwa; David A Stoltz; Douglas B Hornick; Philip M Polgreen
Journal:  Clin Infect Dis       Date:  2022-09-30       Impact factor: 20.999

2.  Repurposing ethyl bromopyruvate as a broad-spectrum antibacterial.

Authors:  Ajay Kumar; Vishant Mahendra Boradia; Ritesh Thakare; Alok Kumar Singh; Zahid Gani; Swetarka Das; Anil Patidar; Arunava Dasgupta; Sidharth Chopra; Manoj Raje; Chaaya Iyengar Raje
Journal:  J Antimicrob Chemother       Date:  2019-04-01       Impact factor: 5.790

3.  Inhalable Nanocomposite Microparticles with Enhanced Dissolution and Superior Aerosol Performance.

Authors:  Chune Zhu; Jianting Chen; Shihui Yu; Chailu Que; Lynne S Taylor; Wen Tan; Chuanbin Wu; Qi Tony Zhou
Journal:  Mol Pharm       Date:  2020-07-24       Impact factor: 4.939

Review 4.  Treatment for chronic methicillin-sensitive Staphylococcus aureus pulmonary infection in people with cystic fibrosis.

Authors:  Molla Imaduddin Ahmed; Saptarshi Mukherjee
Journal:  Cochrane Database Syst Rev       Date:  2018-07-27

5.  Molecular Topology for the Discovery of New Broad-Spectrum Antibacterial Drugs.

Authors:  Jose I Bueso-Bordils; Pedro A Alemán-López; Beatriz Suay-García; Rafael Martín-Algarra; Maria J Duart; Antonio Falcó; Gerardo M Antón-Fos
Journal:  Biomolecules       Date:  2020-09-19
  5 in total

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