Kerrie-Anne Chen1, Fabienne Brilot2, Russell C Dale2, Antony R Lafferty3, Peter Ian Andrews4. 1. Department of Paediatric Neurology, Sydney Children's Hospital, Randwick, Australia. 2. Brain Autoimmunity Group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children's Hospital at Westmead, Sydney Medical School, Brain and Mind Centre, University of Sydney, Sydney, Australia. 3. Department of Paediatrics, The Canberra Hospital, ANU Medical School Canberra, ACT, Australia. 4. Department of Paediatric Neurology, Sydney Children's Hospital, Randwick, Australia; School of Women's and Children's Health, UNSW, Sydney, Australia. Electronic address: ian.andrews@health.nsw.gov.au.
Abstract
PURPOSE: To consider the role of anti-MOG Abs associated encephalitis in Hashimoto's Encephalitis (HE). RESULTS: A 10 year old girl with pre-existing Hashimoto's thyroiditis presented with dysarthria, ataxia and lethargy whilst euthyroid. Brain MRI showed multifocal T2 and FLAIR hyperintense lesions. She responded promptly to treatment with corticosteroids. Her clinical scenario was comparable to a sizeable minority of patients diagnosed with HE in the literature, who have similar brain MRIs. Serum was positive for anti-myelin oligodendrocyte glycoprotein (MOG) Ab, implicating this antibody-mediated process in this patient's illness. CONCLUSION: We hypothesize that anti-MOG Ab associated demyelination may underlie a subset of patients with HE.
PURPOSE: To consider the role of anti-MOG Abs associated encephalitis in Hashimoto's Encephalitis (HE). RESULTS: A 10 year old girl with pre-existing Hashimoto's thyroiditis presented with dysarthria, ataxia and lethargy whilst euthyroid. Brain MRI showed multifocal T2 and FLAIR hyperintense lesions. She responded promptly to treatment with corticosteroids. Her clinical scenario was comparable to a sizeable minority of patients diagnosed with HE in the literature, who have similar brain MRIs. Serum was positive for anti-myelin oligodendrocyte glycoprotein (MOG) Ab, implicating this antibody-mediated process in this patient's illness. CONCLUSION: We hypothesize that anti-MOG Ab associated demyelination may underlie a subset of patients with HE.
Authors: Marina Mané-Damas; Anita Vinke; Carolin Hoffmann; Shenghua Zong; Mario Losen; Peter C Molenaar; Jan Damoiseaux; Suzanne Koudijs; Rob P W Rouhl; Pilar Martinez-Martinez Journal: Front Immunol Date: 2020-07-07 Impact factor: 7.561