Literature DB >> 2869410

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences.

D Martin-Zanca, S H Hughes, M Barbacid.   

Abstract

A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.

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Year:  1986        PMID： 2869410     DOI： 10.1038/319743a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  222 in total

1.  NGF stimulation of erk phosphorylation is impaired by a point mutation in the transmembrane domain of trkA receptor.

Authors:  M Monshipouri; H Jiang; P Lazarovici
Journal:  J Mol Neurosci       Date:  2000 Feb-Apr       Impact factor: 3.444

2.  TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor.

Authors:  J C Arevalo; B Conde; B L Hempstead; M V Chao; D Martin-Zanca; P Perez
Journal:  Mol Cell Biol       Date:  2000-08       Impact factor: 4.272

3.  Separation and identification of differentially expressed nuclear matrix proteins between human esophageal immortalized and carcinomatous cell lines.

Authors:  Xing-Dong Xiong; En-Min Li; Li-Yan Xu; Hai-Bin Chen; Ling Chen; Wei-Jia Cai; Ya-Li Han; Zhong-Ying Shen; Yi Zeng
Journal:  World J Gastroenterol       Date:  2003-10       Impact factor: 5.742

4.  K252a induces anoikis-sensitization with suppression of cellular migration in Epstein-Barr virus (EBV)--associated nasopharyngeal carcinoma cells.

Authors:  Yuen-Keng Ng; Elaine Yue Ling Wong; Cecilia Pik Yuk Lau; Jessica Pui Lan Chan; Sze Chuen Cesar Wong; Andrew Sai-Kit Chan; Maggie Pui Chun Kwan; Sai-Wah Tsao; Chi-Man Tsang; Paul Bo San Lai; Anthony Tak Cheung Chan; Vivian Wai Yan Lui
Journal:  Invest New Drugs       Date:  2010-08-07       Impact factor: 3.850

5.  A novel, plasmid-based system for studying gene rearrangements in mammalian cells.

Authors:  R S Krauss; I B Weinstein
Journal:  Mol Cell Biol       Date:  1991-08       Impact factor: 4.272

6.  Expression and rearrangement of the ROS1 gene in human glioblastoma cells.

Authors:  C Birchmeier; S Sharma; M Wigler
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

7.  Activation of Neu (ErbB-2) mediated by disulfide bond-induced dimerization reveals a receptor tyrosine kinase dimer interface.

Authors:  C L Burke; D F Stern
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272

Review 8.  TRK Inhibition: A New Tumor-Agnostic Treatment Strategy.

Authors:  Shivaani Kummar; Ulrik N Lassen
Journal:  Target Oncol       Date:  2018-10       Impact factor: 4.493

9.  Identification of NTRK3 Fusions in Childhood Melanocytic Neoplasms.

Authors:  Lu Wang; Klaus J Busam; Ryma Benayed; Robert Cimera; Jiajing Wang; Ryan Denley; Mamta Rao; Ruth Aryeequaye; Kerry Mullaney; Long Cao; Marc Ladanyi; Meera Hameed
Journal:  J Mol Diagn       Date:  2017-05       Impact factor: 5.568

10.  Kinase expression and chromosomal rearrangements in papillary thyroid cancer tissues: investigations at the molecular and microscopic levels.

Authors:  H-U G Weier; J Kwan; C-M Lu; Y Ito; M Wang; A Baumgartner; S W Hayward; J F Weier; H F Zitzelsberger
Journal:  J Physiol Pharmacol       Date:  2009-10       Impact factor: 3.011
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