Sara K Tedeschi1, Sindhu R Johnson2, Dimitrios Boumpas3, David Daikh4, Thomas Dörner5, David Jayne6, Diane Kamen7, Kirsten Lerstrøm8, Marta Mosca9, Rosalind Ramsey-Goldman10, Corine Sinnette1, David Wofsy11, Josef S Smolen12, Raymond P Naden13, Martin Aringer14, Karen H Costenbader1. 1. Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. 2. Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada. 3. University of Crete, Heraklion, Greece. 4. University of California at San Francisco and VA Medical Center, San Francisco. 5. Charite University Hospitals, Berlin, Germany. 6. University of Cambridge, Cambridge, UK. 7. Medical University of South Carolina, Charleston. 8. LUPUS EUROPE, Farum, Denmark. 9. University of Pisa, Pisa, Italy. 10. Northwestern University, Chicago, Illinois. 11. University of California at San Francisco. 12. Medical University of Vienna, Vienna Austria. 13. McMaster University, Hamilton, Ontario, Canada. 14. University Medical Center Carl Gustav Carus, Technical University of Dresden, Dresden, Germany.
Abstract
OBJECTIVE: To define candidate criteria within multiphase development of systemic lupus erythematosus (SLE) classification criteria, jointly supported by the American College of Rheumatology and the European League Against Rheumatism. Prior steps included item generation and reduction by Delphi exercise, further narrowed to 21 items in a nominal group technique exercise. Our objectives were to apply an evidence-based approach to the 21 candidate criteria, and to develop hierarchical organization of criteria within domains. METHODS: A literature review identified the sensitivity and specificity of the 21 candidate criteria. Data on the performance of antinuclear antibody (ANA) as an entry criterion and operating characteristics of the candidate criteria in early SLE patients were evaluated. Candidate criteria were hierarchically organized into clinical and immunologic domains, and definitions were refined in an iterative process. RESULTS: Based on the data, consensus was reached to use a positive ANA of ≥1:80 titer (HEp-2 cells immunofluorescence) as an entry criterion and to have 7 clinical and 3 immunologic domains, with hierarchical organization of criteria within domains. Definitions of the candidate criteria were specified. CONCLUSION: Using a data-driven process, consensus was reached on new, refined criteria definitions and organization based on operating characteristics. This work will be followed by a multicriteria decision analysis exercise to weight criteria and to identify a threshold score for classification on a continuous probability scale.
OBJECTIVE: To define candidate criteria within multiphase development of systemic lupus erythematosus (SLE) classification criteria, jointly supported by the American College of Rheumatology and the European League Against Rheumatism. Prior steps included item generation and reduction by Delphi exercise, further narrowed to 21 items in a nominal group technique exercise. Our objectives were to apply an evidence-based approach to the 21 candidate criteria, and to develop hierarchical organization of criteria within domains. METHODS: A literature review identified the sensitivity and specificity of the 21 candidate criteria. Data on the performance of antinuclear antibody (ANA) as an entry criterion and operating characteristics of the candidate criteria in early SLEpatients were evaluated. Candidate criteria were hierarchically organized into clinical and immunologic domains, and definitions were refined in an iterative process. RESULTS: Based on the data, consensus was reached to use a positive ANA of ≥1:80 titer (HEp-2 cells immunofluorescence) as an entry criterion and to have 7 clinical and 3 immunologic domains, with hierarchical organization of criteria within domains. Definitions of the candidate criteria were specified. CONCLUSION: Using a data-driven process, consensus was reached on new, refined criteria definitions and organization based on operating characteristics. This work will be followed by a multicriteria decision analysis exercise to weight criteria and to identify a threshold score for classification on a continuous probability scale.
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Authors: Frank van den Hoogen; Dinesh Khanna; Jaap Fransen; Sindhu R Johnson; Murray Baron; Alan Tyndall; Marco Matucci-Cerinic; Raymond P Naden; Thomas A Medsger; Patricia E Carreira; Gabriela Riemekasten; Philip J Clements; Christopher P Denton; Oliver Distler; Yannick Allanore; Daniel E Furst; Armando Gabrielli; Maureen D Mayes; Jacob M van Laar; James R Seibold; Laszlo Czirjak; Virginia D Steen; Murat Inanc; Otylia Kowal-Bielecka; Ulf Müller-Ladner; Gabriele Valentini; Douglas J Veale; Madelon C Vonk; Ulrich A Walker; Lorinda Chung; David H Collier; Mary Ellen Csuka; Barri J Fessler; Serena Guiducci; Ariane Herrick; Vivien M Hsu; Sergio Jimenez; Bashar Kahaleh; Peter A Merkel; Stanislav Sierakowski; Richard M Silver; Robert W Simms; John Varga; Janet E Pope Journal: Arthritis Rheum Date: 2013-10-03
Authors: Scott A Elman; Cara Joyce; Filippa Nyberg; Fukumi Furukawa; Mark Goodfield; Minoru Hasegawa; Branka Marinovic; Jacek C Szepietowski; Jan Dutz; Victoria P Werth; Joseph F Merola Journal: J Am Acad Dermatol Date: 2017-06-09 Impact factor: 11.527
Authors: Sindhu R Johnson; Jaap Fransen; Dinesh Khanna; Murray Baron; Frank van den Hoogen; Thomas A Medsger; Christine A Peschken; Patricia E Carreira; Gabriela Riemekasten; Alan Tyndall; Marco Matucci-Cerinic; Janet E Pope Journal: Arthritis Care Res (Hoboken) Date: 2012-03 Impact factor: 4.794
Authors: Teresa Aberle; Rebecka L Bourn; Melissa E Munroe; Hua Chen; Virginia C Roberts; Joel M Guthridge; Krista Bean; Julie M Robertson; Kathy L Sivils; Astrid Rasmussen; Meghan Liles; Joan T Merrill; John B Harley; Nancy J Olsen; David R Karp; Judith A James Journal: Arthritis Care Res (Hoboken) Date: 2017-11-14 Impact factor: 4.794
Authors: Sindhu R Johnson; Oemer-Necmi Goek; Davinder Singh-Grewal; Steven C Vlad; Brian M Feldman; David T Felson; Gillian A Hawker; Jasvinder A Singh; Daniel H Solomon Journal: Arthritis Rheum Date: 2007-10-15
Authors: Sara K Tedeschi; Sindhu R Johnson; Dimitrios T Boumpas; David Daikh; Thomas Dörner; Betty Diamond; Søren Jacobsen; David Jayne; Diane L Kamen; W Joseph McCune; Marta Mosca; Rosalind Ramsey-Goldman; Guillermo Ruiz-Irastorza; Matthias Schneider; Murray Urowitz; David Wofsy; Josef S Smolen; Raymond P Naden; Martin Aringer; Karen H Costenbader Journal: Ann Rheum Dis Date: 2019-01-28 Impact factor: 19.103
Authors: Medha Barbhaiya; Stephane Zuily; Yasaman Ahmadzadeh; Mary-Carmen Amigo; Tadej Avcin; Maria Laura Bertolaccini; D Ware Branch; Guilherme de Jesus; Katrien M J Devreese; Camille Frances; David Garcia; Francis Guillemin; Steven R Levine; Roger A Levy; Michael D Lockshin; Thomas L Ortel; Surya V Seshan; Maria Tektonidou; Denis Wahl; Rohan Willis; Ray Naden; Karen Costenbader; Doruk Erkan Journal: Arthritis Care Res (Hoboken) Date: 2021-09-02 Impact factor: 5.178
Authors: Martin Aringer; Karen Costenbader; David Daikh; Ralph Brinks; Marta Mosca; Rosalind Ramsey-Goldman; Josef S Smolen; David Wofsy; Dimitrios T Boumpas; Diane L Kamen; David Jayne; Ricard Cervera; Nathalie Costedoat-Chalumeau; Betty Diamond; Dafna D Gladman; Bevra Hahn; Falk Hiepe; Søren Jacobsen; Dinesh Khanna; Kirsten Lerstrøm; Elena Massarotti; Joseph McCune; Guillermo Ruiz-Irastorza; Jorge Sanchez-Guerrero; Matthias Schneider; Murray Urowitz; George Bertsias; Bimba F Hoyer; Nicolai Leuchten; Chiara Tani; Sara K Tedeschi; Zahi Touma; Gabriela Schmajuk; Branimir Anic; Florence Assan; Tak Mao Chan; Ann Elaine Clarke; Mary K Crow; László Czirják; Andrea Doria; Winfried Graninger; Bernadett Halda-Kiss; Sarfaraz Hasni; Peter M Izmirly; Michelle Jung; Gábor Kumánovics; Xavier Mariette; Ivan Padjen; José M Pego-Reigosa; Juanita Romero-Diaz; Íñigo Rúa-Figueroa Fernández; Raphaèle Seror; Georg H Stummvoll; Yoshiya Tanaka; Maria G Tektonidou; Carlos Vasconcelos; Edward M Vital; Daniel J Wallace; Sule Yavuz; Pier Luigi Meroni; Marvin J Fritzler; Ray Naden; Thomas Dörner; Sindhu R Johnson Journal: Arthritis Rheumatol Date: 2019-08-06 Impact factor: 15.483