Literature DB >> 28692751

Multilevel covariance regression with correlated random effects in the mean and variance structure.

Adrian Quintero1, Emmanuel Lesaffre1.   

Abstract

Multivariate regression methods generally assume a constant covariance matrix for the observations. In case a heteroscedastic model is needed, the parametric and nonparametric covariance regression approaches can be restrictive in the literature. We propose a multilevel regression model for the mean and covariance structure, including random intercepts in both components and allowing for correlation between them. The implied conditional covariance function can be different across clusters as a result of the random effect in the variance structure. In addition, allowing for correlation between the random intercepts in the mean and covariance makes the model convenient for skewedly distributed responses. Furthermore, it permits us to analyse directly the relation between the mean response level and the variability in each cluster. Parameter estimation is carried out via Gibbs sampling. We compare the performance of our model to other covariance modelling approaches in a simulation study. Finally, the proposed model is applied to the RN4CAST dataset to identify the variables that impact burnout of nurses in Belgium.
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords:  Correlated responses; Covariance modeling; Gibbs sampling; Heteroscedastic; Multivariate normal distribution

Mesh:

Year:  2017        PMID: 28692751     DOI: 10.1002/bimj.201600193

Source DB:  PubMed          Journal:  Biom J        ISSN: 0323-3847            Impact factor:   2.207


  2 in total

1.  Bayesian model selection in linear mixed models for longitudinal data.

Authors:  Oludare Ariyo; Adrian Quintero; Johanna Muñoz; Geert Verbeke; Emmanuel Lesaffre
Journal:  J Appl Stat       Date:  2019-08-22       Impact factor: 1.416

2.  Tests for publication bias are unreliable in case of heteroscedasticity.

Authors:  Osama Almalik; Zhuozhao Zhan; Edwin R van den Heuvel
Journal:  Contemp Clin Trials Commun       Date:  2021-06-04
  2 in total

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