Jo Steinson Stenehjem1, Trude Eid Robsahm1, Magne Bråtveit2, Sven Ove Samuelsen3, Jorunn Kirkeleit2,4,5, Tom Kristian Grimsrud1. 1. Department of Research, Cancer Registry of Norway, Oslo, Norway. 2. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. 3. Department of Mathematics, University of Oslo, Oslo, Norway. 4. Department of Clinical Science, University of Bergen, Bergen, Norway. 5. Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.
Abstract
BACKGROUND: We prospectively examined skin cancer risk according to occupational exposure to aromatic hydrocarbons with adjustment for ultraviolet radiation exposure, in a cohort of 24 917 male offshore petroleum workers. METHODS: Hazard ratios (HRs) and 95% confidence intervals were estimated with Cox regression adapted to a stratified case-cohort design. RESULTS: During 13.5 years of follow-up, 112 cutaneous melanomas (CMs) and 70 non-melanoma skin cancers were identified. Increased risks of CM and of squamous cell carcinoma on the forearm and hand were seen among those ever exposed to crude oil or benzene. For skin cancers of the forearm and hand combined, cumulative and duration metrics of benzene exposure showed Ptrends of 0.031 and 0.003, respectively. CONCLUSIONS: Our results support an association between exposure to crude oil or benzene and skin cancer risk on hands and forearms among offshore petroleum workers. Dermal uptake of polycyclic aromatic hydrocarbons or benzene may explain this association.
BACKGROUND: We prospectively examined skin cancer risk according to occupational exposure to aromatic hydrocarbons with adjustment for ultraviolet radiation exposure, in a cohort of 24 917 male offshore petroleum workers. METHODS: Hazard ratios (HRs) and 95% confidence intervals were estimated with Cox regression adapted to a stratified case-cohort design. RESULTS: During 13.5 years of follow-up, 112 cutaneous melanomas (CMs) and 70 non-melanoma skin cancers were identified. Increased risks of CM and of squamous cell carcinoma on the forearm and hand were seen among those ever exposed to crude oil or benzene. For skin cancers of the forearm and hand combined, cumulative and duration metrics of benzene exposure showed Ptrends of 0.031 and 0.003, respectively. CONCLUSIONS: Our results support an association between exposure to crude oil or benzene and skin cancer risk on hands and forearms among offshore petroleum workers. Dermal uptake of polycyclic aromatic hydrocarbons or benzene may explain this association.
Authors: Jo Steinson Stenehjem; Ronnie Babigumira; Melissa C Friesen; Tom Kristian Grimsrud Journal: Am J Ind Med Date: 2019-03-28 Impact factor: 3.079
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