Literature DB >> 28692087

Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery.

Jamie C Gaitor1, Lauren M Paul, Melissa M Reardon, Taha Hmissa, Samuel Minkowicz, Matthew Regner, Yinghong Sheng, Scott F Michael, Sharon Isern, Arsalan Mirjafari.   

Abstract

This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C12 and C14 tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.

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Year:  2017        PMID： 28692087      PMCID： PMC5571731          DOI： 10.1039/c7cc03235h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  14 in total

1.  Tuning the self-assembling of pyridinium cationic lipids for efficient gene delivery into neuronal cells.

Authors:  Sushma Savarala; Eugen Brailoiu; Stephanie L Wunder; Marc A Ilies
Journal:  Biomacromolecules       Date:  2013-07-24       Impact factor: 6.988

2.  Structural basis of DOTMA for its high intravenous transfection activity in mouse.

Authors:  T Ren; Y K Song; G Zhang; D Liu
Journal:  Gene Ther       Date:  2000-05       Impact factor: 5.250

Review 3.  State-of-the-art gene-based therapies: the road ahead.

Authors:  Mark A Kay
Journal:  Nat Rev Genet       Date:  2011-04-06       Impact factor: 53.242

4.  Synthesis of new lipid-inspired ionic liquids by thiol-ene chemistry: profound solvent effect on reaction pathway.

Authors:  Arsalan Mirjafari; Richard A O'Brien; Kevin N West; James H Davis
Journal:  Chemistry       Date:  2014-05-05       Impact factor: 5.236

Review 5.  Synthetic nucleic acid delivery systems: present and perspectives.

Authors:  Bogdan Draghici; Marc A Ilies
Journal:  J Med Chem       Date:  2015-02-20       Impact factor: 7.446

6.  Facile functionalization of polyesters through thiol-yne chemistry for the design of degradable, cell-penetrating and gene delivery dual-functional agents.

Authors:  Zhonghai Zhang; Lichen Yin; Yunxiang Xu; Rong Tong; Yanbing Lu; Jie Ren; Jianjun Cheng
Journal:  Biomacromolecules       Date:  2012-10-26       Impact factor: 6.988

Review 7.  Progress in cationic lipid-mediated gene transfection: a series of bio-inspired lipids as an example.

Authors:  Tristan Montier; Thierry Benvegnu; Paul-Alain Jaffrès; Jean-Jacques Yaouanc; Pierre Lehn
Journal:  Curr Gene Ther       Date:  2008-10       Impact factor: 4.391

8.  A biomimetic lipid library for gene delivery through thiol-yne click chemistry.

Authors:  Linxian Li; David Zahner; Yi Su; Christoph Gruen; Gary Davidson; Pavel A Levkin
Journal:  Biomaterials       Date:  2012-08-16       Impact factor: 12.479

9.  Mesomorphic imidazolium salts: new vectors for efficient siRNA transfection.

Authors:  William Dobbs; Benoît Heinrich; Cyril Bourgogne; Bertrand Donnio; Emmanuel Terazzi; Marie-Elise Bonnet; Fabrice Stock; Patrick Erbacher; Anne-Laure Bolcato-Bellemin; Laurent Douce
Journal:  J Am Chem Soc       Date:  2009-09-23       Impact factor: 15.419

10.  Pyridinium cationic lipids in gene delivery: a structure-activity correlation study.

Authors:  Marc Antoniu Ilies; William A Seitz; Ion Ghiviriga; Betty H Johnson; Aaron Miller; E Brad Thompson; Alexandru T Balaban
Journal:  J Med Chem       Date:  2004-07-15       Impact factor: 7.446
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