Peter Stone1, Walston Martis1, Haemish Crawford2. 1. a Department of Obstetrics and Gynaecology , University of Auckland , Grafton , New Zealand. 2. b Starship Children's Hospital , Auckland , New Zealand.
Abstract
OBJECTIVE: To describe the long-term outcomes of children at school age who were thought to have isolated idiopathic congenital talipes equino varus (ICTEV) at birth. METHOD: A retrospective review of all children attending a regional talipes clinic who had achieved school age. RESULTS: One hundred sixty-three children were followed up. ICTEV was more common in Maori and other Polynesian children and in males. Additional abnormalities were apparent in 30.1% overall, but higher in New Zealand Europeans (43%) than Maori (21%) or other Polynesians (22%). Of the abnormalities, 41% were associated with the central nervous system or with neurodevelopmental delay. Conventional G-band karyotyping, where performed, was not informative. CONCLUSIONS: The rate of additional abnormalities was higher than previous reports. This has implications for prenatal counseling and postnatal follow-up as a prenatal diagnosis of ICTEV may subsequently be found to have longer term implications in addition to orthopedic treatments of the clubfeet.
OBJECTIVE: To describe the long-term outcomes of children at school age who were thought to have isolated idiopathic congenital talipes equino varus (ICTEV) at birth. METHOD: A retrospective review of all children attending a regional talipes clinic who had achieved school age. RESULTS: One hundred sixty-three children were followed up. ICTEV was more common in Maori and other Polynesian children and in males. Additional abnormalities were apparent in 30.1% overall, but higher in New Zealand Europeans (43%) than Maori (21%) or other Polynesians (22%). Of the abnormalities, 41% were associated with the central nervous system or with neurodevelopmental delay. Conventional G-band karyotyping, where performed, was not informative. CONCLUSIONS: The rate of additional abnormalities was higher than previous reports. This has implications for prenatal counseling and postnatal follow-up as a prenatal diagnosis of ICTEV may subsequently be found to have longer term implications in addition to orthopedic treatments of the clubfeet.
Entities:
Keywords:
Club feet outcomes; Maori genetic studies; Pirani score; Polynesian epidemiology of club foot; Ponseti method; prenatal diagnosis club foot
Authors: Jelle F Homans; Terrence B Crowley; Erin Chen; Daniel E McGinn; Vincent F X Deeney; Ralph J B Sakkers; Richard S Davidson; René M Castelein; Donna M McDonald-McGinn Journal: Am J Med Genet A Date: 2018-10 Impact factor: 2.802