| Literature DB >> 28691490 |
Wen-Hua Chiou1, Po-Chou Chen1.
Abstract
A facile formal synthesis to aphanorphine and its analogue is described, featuring Rh-catalyzed cyclohydrocarbonylation of 2-aminodihydronaphthalene to the bridged benzazepine core. Subsequent introduction of the methyl group and functional group transformation complete the synthesis of aphanorphine and its analogue over eight steps.Entities:
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Year: 2017 PMID： 28691490 DOI： 10.1021/acs.joc.7b00923
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354