Martina A Broglie1, Sandro J Stoeckli1, Rafael Sauter2, Philippe Pasche3, Antoine Reinhard3, Laurence de Leval4, Gerhard F Huber5, Thomas F Pezier5, Alex Soltermann6, Roland Giger7, Andreas Arnold7, Matthias Dettmer8, Andre Arnoux9, Martin Müller9, Stefan Spreitzer10, Florian Lang11, Mathieu Lutchmaya11, Edouard Stauffer12, Vittoria Espeli13, Francesco Martucci14, Massimo Bongiovanni4, Diana Foerbs15, Wolfram Jochum15. 1. Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, St. Gallen, Switzerland. 2. Clinical Trials Unit, Kantonsspital St. Gallen, St. Gallen, Switzerland. 3. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Lausanne, Lausanne, Switzerland. 4. Department of Pathology, University Hospital of Lausanne, Lausanne, Switzerland. 5. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Switzerland. 6. Institute of Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland. 7. Department of Otorhinolaryngology, Head and Neck Surgery, Bern University Hospital, Inselspital, Switzerland. 8. Department of Pathology, Bern University Hospital, Inselspital, Switzerland. 9. Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital Aarau, Switzerland. 10. Department of Pathology, Kantonsspital Aarau, Switzerland. 11. Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital Fribourg, Switzerland. 12. Institute of Pathology, Promed SA, Fribourg, Switzerland. 13. Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland. 14. Department of Radiooncology, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland. 15. Institute of Pathology, Kantonsspital St. Gallen, Switzerland.
Abstract
BACKGROUND: Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC. METHODS: Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors. RESULTS: The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%). CONCLUSION: Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.
BACKGROUND: Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC. METHODS: Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors. RESULTS: The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%). CONCLUSION: Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.
Authors: Lisa W Lekanne Dit Deprez; Grégoire B Morand; Christian Thüring; Shila Pazahr; Martin W Hüllner; Martina A Broglie Journal: Eur Arch Otorhinolaryngol Date: 2021-11-15 Impact factor: 2.503
Authors: Stephanie Y Chen; Aisling Last; Abhinav Ettyreddy; Dorina Kallogjeri; Benjamin Wahle; Smrithi Chidambaram; Angela Mazul; Wade Thorstad; Ryan S Jackson; Jose P Zevallos; Patrik Pipkorn Journal: Am J Otolaryngol Date: 2021-01-13 Impact factor: 1.808
Authors: Steve Durante; Vincent Dunet; François Gorostidi; Periklis Mitsakis; Niklaus Schaefer; Judith Delage; John O Prior Journal: EJNMMI Res Date: 2020-05-07 Impact factor: 3.138
Authors: Hani Z Marzouki; Vincent L Biron; Peter T Dziegielewski; Andrew Ma; Jason Vaz; Gabriela Constantinescu; Jeffrey Harris; Daniel O'Connell; Hadi Seikaly Journal: J Otolaryngol Head Neck Surg Date: 2018-09-19