Literature DB >> 28691107

Network-based approaches that exploit inferred transcription factor activity to analyze the impact of genetic variation on gene expression.

Harmen J Bussemaker1,2, Helen C Causton3, Mina Fazlollahi4, Eunjee Lee4, Ivor Muroff1.   

Abstract

Over the past decade, a number of methods have emerged for inferring protein-level transcription factor activities in individual samples based on prior information about the structure of the gene regulatory network. We discuss how this has enabled new methods for dissecting trans-acting mechanisms that underpin genetic variation in gene expression.

Entities:  

Keywords:  QTL mapping; gene regulatory networks; systems genetics; transcription factor activity

Year:  2017        PMID： 28691107      PMCID： PMC5499699          DOI： 10.1016/j.coisb.2017.04.002

Source DB:  PubMed          Journal:  Curr Opin Syst Biol        ISSN： 2452-3100


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