Literature DB >> 28690899

Struma Ovarii with Pseudo-Meigs' Syndrome and Raised Cancer Antigen-125 Levels Masquerading as an Ovarian Carcinoma Case report and literature review.

Surekha Yadav1, Reena Tomar1, Nidhi Verma1, Nita Khurana1, Rewa Triathi2.   

Abstract

The monodermal teratoma struma ovarii is a rare ovarian tumour; however, struma ovarii presenting with pseudo-Meigs' syndrome and raised cancer antigen (CA)-125 levels is even rarer. In elderly patients, this presentation can potentially lead to a misdiagnosis of a malignant ovarian carcinoma, resulting in unnecessary extensive surgery. We report a 55-year-old female who presented to the Lok Nayak Jai Prakash Narayan Hospital, New Delhi, India, in 2016 with progressive abdominal discomfort, fatigue and abdominal distention. Clinical and radiological features were indicative of a malignant ovarian tumour and ascites. Serum CA-125 levels were elevated at 258 U/mL. A left-sided salpingo-oophorectomy was performed, after which the serum CA-125 levels normalised. There was no evidence of recurrence at a six-month follow-up. A frozen section procedure confirmed the diagnosis of a struma ovarii. This rare condition should be considered as a differential diagnosis in patients presenting with ovarian masses, ascites and raised CA-125 levels.

Entities:  

Keywords:  Ascites; Carcinoma; Case Report; Frozen Section; India; Meigs’ Syndrome; Ovarian Cancers; Struma Ovarii

Mesh:

Substances:

Year:  2017        PMID: 28690899      PMCID: PMC5488828          DOI: 10.18295/squmj.2016.17.02.017

Source DB:  PubMed          Journal:  Sultan Qaboos Univ Med J        ISSN: 2075-051X


  25 in total

1.  Struma ovarii: a rare benign pathology which may erroneously suggest malignancy.

Authors:  A Mancuso; O Triolo; I Leonardi; A De Vivo
Journal:  Acta Obstet Gynecol Scand       Date:  2001-11       Impact factor: 3.636

2.  Struma ovarii associated with pseudo-Meigs' syndrome and elevated serum CA 125: a case report and review of the literature.

Authors:  Wei Jiang; Xin Lu; Zhi Ling Zhu; Xi Shi Liu; Cong Jian Xu
Journal:  J Ovarian Res       Date:  2010-07-29       Impact factor: 4.234

3.  Three cases of struma ovarii underwent laparoscopic surgery with definite preoperative diagnosis.

Authors:  Tomoyuki Kusumoto; Seiji Inoue; Keiichiro Nakamura; Noriko Seki; Atsushi Hongo; Junichi Kodama; Yuji Hiramatsu
Journal:  Acta Med Okayama       Date:  2013       Impact factor: 0.892

4.  An unusual presentation of struma ovarii mimicking a malignant process.

Authors:  Vera Loizzi; Fabio Cappuccini; Michael L Berman
Journal:  Obstet Gynecol       Date:  2002-11       Impact factor: 7.661

5.  Pseudo-Meigs syndrome and elevated levels of tumor markers associated with benign ovarian tumors--two case reports.

Authors:  C Y Long; Y H Chen; S C Chen; J N Lee; J H Su; S C Hsu
Journal:  Kaohsiung J Med Sci       Date:  2001-11       Impact factor: 2.744

6.  Cystic struma ovarii presenting with ascites and an elevated CA-125 level. A case report.

Authors:  Aqiba Bokhari; Ginni S Rosenfeld; Bemadette Cracchiolo; Debra S Heller
Journal:  J Reprod Med       Date:  2003-01       Impact factor: 0.142

7.  Limitations of CA125 in the preoperative evaluation of a pelvic mass: struma ovarii and ascites.

Authors:  Y C Leung; I G Hammond
Journal:  Aust N Z J Obstet Gynaecol       Date:  1993-05       Impact factor: 2.100

Review 8.  Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature.

Authors:  S Mitrou; S Manek; S Kehoe
Journal:  Int J Gynecol Cancer       Date:  2008 Mar-Apr       Impact factor: 3.437

Review 9.  Struma ovarii with pseudo-Meigs' syndrome: report of a case and review of the literature.

Authors:  S S Amr; A A Hassan
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  1994-06-30       Impact factor: 2.435

Review 10.  The CA 125 tumour-associated antigen: a review of the literature.

Authors:  I Jacobs; R C Bast
Journal:  Hum Reprod       Date:  1989-01       Impact factor: 6.918

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  3 in total

1.  Meigs' Versus Pseudo-Meigs' Syndrome: A Case of Pleural Effusion, Ascites, and Ovarian Mass.

Authors:  Paul Nguyen; Omid Yazdanpanah; Brianna Schumaker
Journal:  Cureus       Date:  2020-08-12

2.  Struma Ovarii Associated with Ascites and Elevated CA125: Two Case Reports and Review of the Literature.

Authors:  Shaoyu Wang; Xinqin He; Huijuan Yang; Lihong Chen
Journal:  Int J Womens Health       Date:  2022-09-07

Review 3.  Precise preoperative diagnosis of struma ovarii with pseudo-Meigs' syndrome mimicking ovarian cancer with the combination of 131I scintigraphy and 18F-FDG PET: case report and review of the literature.

Authors:  Sayaka Fujiwara; Hideaki Tsuyoshi; Toshiya Nishimura; Nozomu Takahashi; Yoshio Yoshida
Journal:  J Ovarian Res       Date:  2018-02-02       Impact factor: 4.234

  3 in total

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