| Literature DB >> 28690082 |
Le Son Tran1, Michelle Chonwerawong1, Richard L Ferrero2.
Abstract
Persistent stomach infection with Helicobacter pylori causes chronic mucosal inflammation (gastritis), which is widely recognized as an essential precursor to gastric cancer. The IL-1 interleukin family cytokines IL-1β and IL-18 have emerged as central mediators of mucosal inflammation. Here, we review the regulation and functions of these cytokines in H. pylori-induced inflammation and carcinogenesis.Entities:
Keywords: Gastric cancer; Helicobacter pylori; IL-18; IL-1β; Inflammasome; NOD-like receptors
Mesh:
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Year: 2017 PMID: 28690082 DOI: 10.1016/j.micinf.2017.06.005
Source DB: PubMed Journal: Microbes Infect ISSN: 1286-4579 Impact factor: 2.700