João Cavaleiro Rufo1, André Moreira2, Luís Delgado3. 1. Basic and Clinical Immunology, Faculty of Medicine, University of Porto, Porto, Portugal; EPIUnit, Institute of Public Health of the University of Porto, Porto, Portugal; Energy and Built Environment Group, Institute of Science and Innovation in Mechanical and Industrial Engineering, Porto, Portugal. Electronic address: jcrufo@gmail.com. 2. Basic and Clinical Immunology, Faculty of Medicine, University of Porto, Porto, Portugal; EPIUnit, Institute of Public Health of the University of Porto, Porto, Portugal; São João Hospital Center, Porto, Portugal. 3. Basic and Clinical Immunology, Faculty of Medicine, University of Porto, Porto, Portugal; São João Hospital Center, Porto, Portugal.