Literature DB >> 28689793

A single amino acid in MRGPRX2 necessary for binding and activation by pruritogens.

Vemuri B Reddy1, Thomas A Graham2, Ehsan Azimi1, Ethan A Lerner3.   

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Year:  2017        PMID： 28689793      PMCID： PMC5723232          DOI： 10.1016/j.jaci.2017.05.046

Source DB:  PubMed          Journal:  J Allergy Clin Immunol        ISSN： 0091-6749            Impact factor:   10.793


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  11 in total

1.  Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization.

Authors:  Hariharan Subramanian; Kshitij Gupta; Qiang Guo; Ryan Price; Hydar Ali
Journal:  J Biol Chem       Date:  2011-11-08       Impact factor: 5.157

2.  Substance P activates Mas-related G protein-coupled receptors to induce itch.

Authors:  Ehsan Azimi; Vemuri B Reddy; Paula Juliana Seadi Pereira; Sebastien Talbot; Clifford J Woolf; Ethan A Lerner
Journal:  J Allergy Clin Immunol       Date:  2017-02-20       Impact factor: 10.793

3.  Clustal W and Clustal X version 2.0.

Authors:  M A Larkin; G Blackshields; N P Brown; R Chenna; P A McGettigan; H McWilliam; F Valentin; I M Wallace; A Wilm; R Lopez; J D Thompson; T J Gibson; D G Higgins
Journal:  Bioinformatics       Date:  2007-09-10       Impact factor: 6.937

4.  Cathelicidin LL-37 Induces Semaphorin 3A Expression in Human Epidermal Keratinocytes: Implications for Possible Application to Pruritus.

Authors:  Yoshie Umehara; Yayoi Kamata; Mitsutoshi Tominaga; François Niyonsaba; Hideoki Ogawa; Kenji Takamori
Journal:  J Invest Dermatol       Date:  2015-06-29       Impact factor: 8.551

5.  Dual action of neurokinin-1 antagonists on Mas-related GPCRs.

Authors:  Ehsan Azimi; Vemuri B Reddy; Kai-Ting C Shade; Robert M Anthony; Sebastien Talbot; Paula Juliana Seadi Pereira; Ethan A Lerner
Journal:  JCI Insight       Date:  2016-10-06

6.  Endogenous antimicrobial peptides and skin infections in atopic dermatitis.

Authors:  Peck Y Ong; Takaaki Ohtake; Corinne Brandt; Ian Strickland; Mark Boguniewicz; Tomas Ganz; Richard L Gallo; Donald Y M Leung
Journal:  N Engl J Med       Date:  2002-10-10       Impact factor: 91.245

7.  MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.

Authors:  Nicola Robas; Emma Mead; Mark Fidock
Journal:  J Biol Chem       Date:  2003-08-12       Impact factor: 5.157

8.  Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions.

Authors:  Benjamin D McNeil; Priyanka Pundir; Sonya Meeker; Liang Han; Bradley J Undem; Marianna Kulka; Xinzhong Dong
Journal:  Nature       Date:  2014-12-17       Impact factor: 49.962

9.  In silico design of novel probes for the atypical opioid receptor MRGPRX2.

Authors:  Katherine Lansu; Joel Karpiak; Jing Liu; Xi-Ping Huang; John D McCorvy; Wesley K Kroeze; Tao Che; Hiroshi Nagase; Frank I Carroll; Jian Jin; Brian K Shoichet; Bryan L Roth
Journal:  Nat Chem Biol       Date:  2017-03-13       Impact factor: 15.040

10.  The Phyre2 web portal for protein modeling, prediction and analysis.

Authors:  Lawrence A Kelley; Stefans Mezulis; Christopher M Yates; Mark N Wass; Michael J E Sternberg
Journal:  Nat Protoc       Date:  2015-05-07       Impact factor: 13.491
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  15 in total

1.  Naturally Occurring Missense MRGPRX2 Variants Display Loss of Function Phenotype for Mast Cell Degranulation in Response to Substance P, Hemokinin-1, Human β-Defensin-3, and Icatibant.

Authors:  Ibrahim Alkanfari; Kshitij Gupta; Tahsin Jahan; Hydar Ali
Journal:  J Immunol       Date:  2018-05-23       Impact factor: 5.422

2.  Lactic acid suppresses MRGPRX2 mediated mast cell responses.

Authors:  Meesum Syed; Ananth K Kammala; Brianna Callahan; Carole A Oskeritzian; Hariharan Subramanian
Journal:  Cell Immunol       Date:  2021-08-08       Impact factor: 4.178

Review 3.  Physiology and Pathophysiology of Itch.

Authors:  Ferda Cevikbas; Ethan A Lerner
Journal:  Physiol Rev       Date:  2019-12-23       Impact factor: 37.312

Review 4.  Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease.

Authors:  Saptarshi Roy; Chalatip Chompunud Na Ayudhya; Monica Thapaliya; Vishwa Deepak; Hydar Ali
Journal:  J Allergy Clin Immunol       Date:  2021-05-04       Impact factor: 14.290

Review 5.  Mast Cell-Specific MRGPRX2: a Key Modulator of Neuro-Immune Interaction in Allergic Diseases.

Authors:  Monica Thapaliya; Chalatip Chompunud Na Ayudhya; Aetas Amponnawarat; Saptarshi Roy; Hydar Ali
Journal:  Curr Allergy Asthma Rep       Date:  2021-01-04       Impact factor: 4.919

6.  Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions.

Authors:  Grzegorz Porebski; Kamila Kwiecien; Magdalena Pawica; Mateusz Kwitniewski
Journal:  Front Immunol       Date:  2018-12-20       Impact factor: 7.561

7.  Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization.

Authors:  Chalatip Chompunud Na Ayudhya; Aetas Amponnawarat; Hydar Ali
Journal:  Int J Mol Sci       Date:  2021-05-18       Impact factor: 5.923

8.  Identification of Gain and Loss of Function Missense Variants in MRGPRX2's Transmembrane and Intracellular Domains for Mast Cell Activation by Substance P.

Authors:  Chalatip Chompunud Na Ayudhya; Saptarshi Roy; Ibrahim Alkanfari; Anirban Ganguly; Hydar Ali
Journal:  Int J Mol Sci       Date:  2019-10-23       Impact factor: 6.208

9.  Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by a Single-Stranded Oligonucleotide.

Authors:  Aleksandra Dondalska; Elin Rönnberg; Haisha Ma; Sandra Axberg Pålsson; Elin Magnusdottir; Tianle Gao; Lucille Adam; Ethan A Lerner; Gunnar Nilsson; Malin Lagerström; Anna-Lena Spetz
Journal:  Front Immunol       Date:  2020-09-30       Impact factor: 7.561

10.  Identification of the dog orthologue of human MAS-related G protein coupled receptor X2 (MRGPRX2) essential for drug-induced pseudo-allergic reactions.

Authors:  Eri Hamamura-Yasuno; Takuma Iguchi; Kazuyoshi Kumagai; Yoshimi Tsuchiya; Kazuhiko Mori
Journal:  Sci Rep       Date:  2020-09-30       Impact factor: 4.379
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