Literature DB >> 28689224

Mixed papillary-sarcomatoid carcinoma of the penis: report of an aggressive subtype.

Graziele Bovolim1, Walter Henriques da Costa2, Gustavo Cardoso Guimaraes2, Fernando Augusto Soares1, Isabela Werneck da Cunha3.   

Abstract

Several different histological subtypes of penile carcinoma had been described in the last decades, many with different biological behavior and prognosis. The association of two histological subtypes (mixed tumors) can be observed in one third of the cases. The most common association is of warty and basaloid tumors, two HPV-related carcinomas. Here, we described a mixed papillary-sarcomatoid carcinoma, never reported before. Although it is a clinical aspect of a low-grade verruciform tumor, its prognosis showed it to be very aggressive due to the sarcomatoid component hidden above the papillary component. The two components showed opposite cadherin/vimentin expression pointed to epithelial-mesenchymal transition between them.

Entities:  

Keywords:  Epithelial-mesenchymal transition; Male cancer; Penile carcinoma; sarcomatoid differentiation; Penile malignancies

Mesh：

Year:  2017        PMID： 28689224     DOI： 10.1007/s00428-017-2191-2

Source DB:  PubMed          Journal:  Virchows Arch        ISSN： 0945-6317            Impact factor:   4.064


  9 in total

1.  Sarcomatoid carcinoma of the penis: a clinicopathologic study of 15 cases.

Authors:  Elsa F Velazquez; Jonathan Melamed; Jose E Barreto; Fatima Aguero; Antonio L Cubilla
Journal:  Am J Surg Pathol       Date:  2005-09       Impact factor: 6.394

2.  Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence.

Authors:  Judith Oertell; Carmelo Caballero; Manuelita Iglesias; Alcides Chaux; Luís Amat; Enrique Ayala; Ingrid Rodríguez; Elsa F Velázquez; José E Barreto; Gustavo Ayala; Antonio L Cubilla
Journal:  Histopathology       Date:  2011-05       Impact factor: 5.087

3.  Pathological factors, behavior, and histological prognostic risk groups in subtypes of penile squamous cell carcinomas (SCC).

Authors:  Diego F Sanchez; Fernando Soares; Isabel Alvarado-Cabrero; Sofía Cañete; María José Fernández-Nestosa; Ingrid M Rodríguez; José Barreto; Antonio L Cubilla
Journal:  Semin Diagn Pathol       Date:  2014-12-27       Impact factor: 3.464

4.  Epithelial-mesenchymal transition (EMT) phenotype at invasion front of squamous cell carcinoma of the penis influences oncological outcomes.

Authors:  Isabela Werneck da Cunha; Maria José L Souza; Walter Henriques da Costa; Alice M Amâncio; Francisco Paulo Fonseca; Stenio de Cassio Zequi; Ademar Lopes; Gustavo Cardoso Guimarães; Fernando Soares
Journal:  Urol Oncol       Date:  2016-07-02       Impact factor: 3.498

5.  The prognostic index: a useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma.

Authors:  Alcides Chaux; Carmelo Caballero; Fernando Soares; Gustavo C Guimarães; Isabel W Cunha; Víctor Reuter; José Barreto; Ingrid Rodríguez; Antonio L Cubilla
Journal:  Am J Surg Pathol       Date:  2009-07       Impact factor: 6.394

Review 6.  The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours.

Authors:  Peter A Humphrey; Holger Moch; Antonio L Cubilla; Thomas M Ulbright; Victor E Reuter
Journal:  Eur Urol       Date:  2016-03-17       Impact factor: 20.096

7.  Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases.

Authors:  Alcides Chaux; Victor Reuter; Cecilia Lezcano; Elsa F Velazquez; Jose Torres; Antonio L Cubilla
Journal:  Am J Surg Pathol       Date:  2009-09       Impact factor: 6.394

8.  Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: clinicopathologic features, differential diagnosis, and outcome of 35 cases.

Authors:  Alcides Chaux; Fernando Soares; Ingrid Rodríguez; José Barreto; Cecilia Lezcano; José Torres; Elsa F Velazquez; Antonio L Cubilla
Journal:  Am J Surg Pathol       Date:  2010-02       Impact factor: 6.394

9.  Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.

Authors:  Gustavo Cardoso Guimarães; Isabela Werneck Cunha; Fernando Augusto Soares; Ademar Lopes; Jose Torres; Alcides Chaux; Elsa F Velazquez; Gustavo Ayala; Antonio L Cubilla
Journal:  J Urol       Date:  2009-06-13       Impact factor: 7.450
  9 in total

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