| Literature DB >> 28688943 |
Zheng Gao1, Juan Li2, Xinling Song1, Jianjun Zhang1, Xiuxiu Wang1, Huijuan Jing1, Zhenzhen Ren1, Shangshang Li1, Chen Zhang1, Le Jia3.
Abstract
The present work was designed to investigated the antioxidant, anti-inflammation, and pulmonary protective effects of SMPS and MPS from Oudemansiella radicata on LPS-induced lung injured mice. The results demonstrated that SMPS showed potential effects on relieving lung injury and preventing oxidative stress, reflecting by decreasing the serum levels of C3, CRP and GGT, increasing the pulmonary activities of SOD, GSH-Px, CAT and T-AOC, as well as down-regulating the MDA and LPO contents, respectively. Furthermore, the levels of TNF-α (224.211±3.12ng/mL), IL-1β (254.557±2.18ng/L), and IL-6 (18.214±0.15ng/L) in BALF of mice treated with SMPS at the dosage of 400mg/kg/d significantly lower than that in the lung injured mice. These conclusions indicated that both SMPS and MPS possessed potent antioxidants and anti-inflammation activities, and could be used as functional foods and natural drugs in preventing lung injury.Entities:
Keywords: Anti-inflammation; Antioxidative effects; Lung-protective effects; Oudemansiella radicata; Selenium polysaccharides
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Year: 2017 PMID： 28688943 DOI： 10.1016/j.ijbiomac.2017.07.029
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953