Egon Burian1, Caterina Schulz2, Florian Probst2, Benjamin Palla3, Matthias Tröltzsch2, Fabio Maglitto4, Luigi Califano4, Michael Ehrenfeld2, Sven Otto2. 1. Department of Oral and Maxillofacial Surgery (Chair: M. Ehrenfeld MD, DDS, PhD), Ludwig-Maximilians-University, Lindwurmstraße 2a, 80336 Munich, Germany. Electronic address: e.burian@gmx.net. 2. Department of Oral and Maxillofacial Surgery (Chair: M. Ehrenfeld MD, DDS, PhD), Ludwig-Maximilians-University, Lindwurmstraße 2a, 80336 Munich, Germany. 3. Harvard School of Dental Medicine (Chair: R. Bruce Donoff MD, DMD), 188 Longwood Ave, Boston, MA, 02115 USA. 4. Head and Neck Section, Department of Neurosciences, Reproductive and Odontostomatological Science (Chair: L. Califano MD, PhD), Frederico II University of Naples, Via s. Pansini 5, 80138 Napoli, Italy.
Abstract
OBJECTIVES: Several diagnostic tools have been developed to assess benign and potentially malignant disorders of soft tissues. In this study, we aimed to assess the value of the VELscope® (Visually Enhanced Light Scope) imaging device as a technical tool to investigate malignant lesions of the oral cavity. MATERIAL AND METHODS: In this retrospective study we analyzed the photographs of 90 patients who suffered from malignant oral soft tissue lesions or carcinoma in situ (CIS) from 2008 to 2014 in the Clinic of Oral and Maxillofacial Surgery of LMU in Munich. RESULTS: In 85.6% of the cases fluorescence quenching/loss could be detected. The average value for the colour red shows a significant difference in pathologic and physiologic tissues (p = 0.007) with a higher median for pathologic tissues. For the colours green and blue our measurements show significantly higher values in the healthy tissue (p < 0.001.). The shade of red showed significantly higher values for pathologic tissues when compared to all three colours (p < 0.001). Furthermore, the shades of green and blue showed significantly lower values in the pathologic tissue (p < 0.001). CONCLUSION: In the near future, VELscope® could help to a greater extent than visual observation alone in identifying the margins of tumor resections. VELscope® still lacks the ability to identify the overall risk level of oral lesions.
OBJECTIVES: Several diagnostic tools have been developed to assess benign and potentially malignant disorders of soft tissues. In this study, we aimed to assess the value of the VELscope® (Visually Enhanced Light Scope) imaging device as a technical tool to investigate malignant lesions of the oral cavity. MATERIAL AND METHODS: In this retrospective study we analyzed the photographs of 90 patients who suffered from malignant oral soft tissue lesions or carcinoma in situ (CIS) from 2008 to 2014 in the Clinic of Oral and Maxillofacial Surgery of LMU in Munich. RESULTS: In 85.6% of the cases fluorescence quenching/loss could be detected. The average value for the colour red shows a significant difference in pathologic and physiologic tissues (p = 0.007) with a higher median for pathologic tissues. For the colours green and blue our measurements show significantly higher values in the healthy tissue (p < 0.001.). The shade of red showed significantly higher values for pathologic tissues when compared to all three colours (p < 0.001). Furthermore, the shades of green and blue showed significantly lower values in the pathologic tissue (p < 0.001). CONCLUSION: In the near future, VELscope® could help to a greater extent than visual observation alone in identifying the margins of tumor resections. VELscope® still lacks the ability to identify the overall risk level of oral lesions.
Authors: Marco Cicciù; Gabriele Cervino; Luca Fiorillo; Cesare D'Amico; Giacomo Oteri; Giuseppe Troiano; Khrystyna Zhurakivska; Lorenzo Lo Muzio; Alan Scott Herford; Salvatore Crimi; Alberto Bianchi; Dario Di Stasio; Rosario Rullo; Gregorio Laino; Luigi Laino Journal: Dent J (Basel) Date: 2019-09-04
Authors: Oliver Ristow; Dirk Nehrbass; Stephan Zeiter; Daniel Arens; Julius Moratin; Christoph Pautke; Jürgen Hoffmann; Christian Freudlsperger; Sven Otto Journal: Clin Oral Investig Date: 2020-05-22 Impact factor: 3.573