Patompong Ungprasert1,2, Katelynn M Wilton3, Floranne C Ernste4, Sanjay Kalra5, Cynthia S Crowson1,6, Srinivasan Rajagopalan7, Brian J Bartholmai8. 1. Division of Rheumatology, Department of Medicine, Mayo Clinic in Rochester, Mayo East15, 200 First Street SW, Rochester, MN, 55905, USA. 2. Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Siriraj Hospital in Bangkok, Bangkok, Thailand. 3. Mayo Medical Scientist Training Program, Mayo Clinic in Rochester, Rochester, MN, USA. 4. Division of Rheumatology, Department of Medicine, Mayo Clinic in Rochester, Mayo East15, 200 First Street SW, Rochester, MN, 55905, USA. ernste.floranne@mayo.edu. 5. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic in Rochester, Rochester, MN, USA. 6. Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic in Rochester, Rochester, MN, USA. 7. Department of Physiology and Biomedical Engineering, Biomedical Imaging Resource, Mayo Clinic in Rochester, Rochester, MN, USA. 8. Department of Radiology, Mayo Clinic in Rochester, Rochester, MN, USA.
Abstract
PURPOSE: To evaluate the correlation between measurements from quantitative thoracic high-resolution CT (HRCT) analysis with "Computer-Aided Lung Informatics for Pathology Evaluation and Rating" (CALIPER) software and measurements from pulmonary function tests (PFTs) in patients with idiopathic inflammatory myopathies (IIM)-associated interstitial lung disease (ILD). METHODS: A cohort of patients with IIM-associated ILD seen at Mayo Clinic was identified from medical record review. Retrospective analysis of HRCT data and PFTs at baseline and 1 year was performed. The abnormalities in HRCT were quantified using CALIPER software. RESULTS: A total of 110 patients were identified. At baseline, total interstitial abnormalities as measured by CALIPER, both by absolute volume and by percentage of total lung volume, had a significant negative correlation with diffusing capacity for carbon monoxide (DLCO), total lung capacity (TLC), and oxygen saturation. Analysis by subtype of interstitial abnormality revealed significant negative correlations between ground glass opacities (GGO) and reticular density (RD) with DLCO and TLC. At one year, changes of total interstitial abnormalities compared with baseline had a significant negative correlation with changes of TLC and oxygen saturation. A negative correlation between changes of total interstitial abnormalities and DLCO was also observed, but it was not statistically significant. Analysis by subtype of interstitial abnormality revealed negative correlations between changes of GGO and RD and changes of DLCO, TLC, and oxygen saturation, but most of the correlations did not achieve statistical significance. CONCLUSION: CALIPER measurements correlate well with functional measurements in patients with IIM-associated ILD.
PURPOSE: To evaluate the correlation between measurements from quantitative thoracic high-resolution CT (HRCT) analysis with "Computer-Aided Lung Informatics for Pathology Evaluation and Rating" (CALIPER) software and measurements from pulmonary function tests (PFTs) in patients with idiopathic inflammatory myopathies (IIM)-associated interstitial lung disease (ILD). METHODS: A cohort of patients with IIM-associated ILD seen at Mayo Clinic was identified from medical record review. Retrospective analysis of HRCT data and PFTs at baseline and 1 year was performed. The abnormalities in HRCT were quantified using CALIPER software. RESULTS: A total of 110 patients were identified. At baseline, total interstitial abnormalities as measured by CALIPER, both by absolute volume and by percentage of total lung volume, had a significant negative correlation with diffusing capacity for carbon monoxide (DLCO), total lung capacity (TLC), and oxygen saturation. Analysis by subtype of interstitial abnormality revealed significant negative correlations between ground glass opacities (GGO) and reticular density (RD) with DLCO and TLC. At one year, changes of total interstitial abnormalities compared with baseline had a significant negative correlation with changes of TLC and oxygen saturation. A negative correlation between changes of total interstitial abnormalities and DLCO was also observed, but it was not statistically significant. Analysis by subtype of interstitial abnormality revealed negative correlations between changes of GGO and RD and changes of DLCO, TLC, and oxygen saturation, but most of the correlations did not achieve statistical significance. CONCLUSION: CALIPER measurements correlate well with functional measurements in patients with IIM-associated ILD.
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