Literature DB >> 28687684

Transient neonatal hypercalcaemia secondary to excess maternal vitamin D intake: too much of a good thing.

Adam Reynolds1, Susan M O'Connell2, Louise Clare Kenny3,4, Eugene Dempsey1,4.   

Abstract

We report a case of transient neonatal hypercalcaemia secondary to excess maternal vitamin D intake in pregnancy. Vitamin D insufficiency and deficiency in pregnancy are associated with adverse pregnancy outcomes, but there is no definite benefit to supplementation. The Royal College of Obstetrics and Gynaecology recommends routine supplementation with vitamin D3 400 IU/day, but higher dose preparations usually recommended for the treatment of vitamin D deficiency are readily available over the counter. This case highlights the risks of excess supplementation, especially at higher doses and in women without evidence of vitamin D deficiency. The amount used in this case was at the upper end of the generally accepted safe dose range, but still less than that commonly recognised to cause problems. Neonatal hypercalcaemia is a potentially serious condition. The current local or national recommendations for vitamin D supplementation and the possible adverse effects of excess vitamin D consumption should be clearly communicated to pregnant women. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Entities:  

Keywords:  Drugs: obstetrics and gynaecology; Materno-fetal medicine; Obstetrics, gynaecology and fertility; Vitamins and supplements

Mesh:

Substances:

Year:  2017        PMID: 28687684      PMCID: PMC5534804          DOI: 10.1136/bcr-2016-219043

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  16 in total

1.  EFFECT OF PREGNANCY AND OF THE MENSTRUAL CYCLE ON HYPOPARATHYROIDISM.

Authors:  W P GRAHAM; G S GORDAN; H F LOKEN; A BLUM; A HALDEN
Journal:  J Clin Endocrinol Metab       Date:  1964-06       Impact factor: 5.958

Review 2.  Risk assessment for vitamin D.

Authors:  John N Hathcock; Andrew Shao; Reinhold Vieth; Robert Heaney
Journal:  Am J Clin Nutr       Date:  2007-01       Impact factor: 7.045

3.  Prevalence of suboptimal vitamin D status during pregnancy.

Authors:  M N O'Riordan; M Kiely; J R Higgins; K D Cashman
Journal:  Ir Med J       Date:  2008-09

Review 4.  Hypercalcemia of the newborn: etiology, evaluation, and management.

Authors:  C Rodd; P Goodyer
Journal:  Pediatr Nephrol       Date:  1999-08       Impact factor: 3.714

Review 5.  Vitamin D supplementation during pregnancy: safety considerations in the design and interpretation of clinical trials.

Authors:  D E Roth
Journal:  J Perinatol       Date:  2011-01-20       Impact factor: 2.521

6.  ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy.

Authors: 
Journal:  Obstet Gynecol       Date:  2011-07       Impact factor: 7.661

7.  Maternal vitamin D and fetal growth in early-onset severe preeclampsia.

Authors:  Christopher J Robinson; Carol L Wagner; Bruce W Hollis; John E Baatz; Donna D Johnson
Journal:  Am J Obstet Gynecol       Date:  2011-03-16       Impact factor: 8.661

8.  Maternal and postnatal vitamin D ingestion influences rat aortic structure, function and elastin content.

Authors:  Paul Norman; Ian Moss; Minder Sian; Martin Gosling; Janet Powell
Journal:  Cardiovasc Res       Date:  2002-08-01       Impact factor: 10.787

Review 9.  Assessment of dietary vitamin D requirements during pregnancy and lactation.

Authors:  Bruce W Hollis; Carol L Wagner
Journal:  Am J Clin Nutr       Date:  2004-05       Impact factor: 7.045

10.  Maternal vitamin D status during pregnancy and child outcomes.

Authors:  C R Gale; S M Robinson; N C Harvey; M K Javaid; B Jiang; C N Martyn; K M Godfrey; C Cooper
Journal:  Eur J Clin Nutr       Date:  2007-02-21       Impact factor: 4.016

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  2 in total

1.  Vitamin D Intoxication Presenting as Subacute Encephalopathy-A Case Report.

Authors:  Naik Tripty; Jagzape Tushar; Jondhale Sunil
Journal:  Child Neurol Open       Date:  2021-04-29

2.  Severe hypercalcemia associated with hypophosphatemia in very premature infants: a case report.

Authors:  Nicola Improda; Francesca Mazzeo; Alessandro Rossi; Claudia Rossi; Francesco Paolo Improda; Angelo Izzo
Journal:  Ital J Pediatr       Date:  2021-07-07       Impact factor: 2.638

  2 in total

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