| Literature DB >> 28687684 |
Adam Reynolds1, Susan M O'Connell2, Louise Clare Kenny3,4, Eugene Dempsey1,4.
Abstract
We report a case of transient neonatal hypercalcaemia secondary to excess maternal vitamin D intake in pregnancy. Vitamin D insufficiency and deficiency in pregnancy are associated with adverse pregnancy outcomes, but there is no definite benefit to supplementation. The Royal College of Obstetrics and Gynaecology recommends routine supplementation with vitamin D3 400 IU/day, but higher dose preparations usually recommended for the treatment of vitamin D deficiency are readily available over the counter. This case highlights the risks of excess supplementation, especially at higher doses and in women without evidence of vitamin D deficiency. The amount used in this case was at the upper end of the generally accepted safe dose range, but still less than that commonly recognised to cause problems. Neonatal hypercalcaemia is a potentially serious condition. The current local or national recommendations for vitamin D supplementation and the possible adverse effects of excess vitamin D consumption should be clearly communicated to pregnant women. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.Entities:
Keywords: Drugs: obstetrics and gynaecology; Materno-fetal medicine; Obstetrics, gynaecology and fertility; Vitamins and supplements
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Year: 2017 PMID: 28687684 PMCID: PMC5534804 DOI: 10.1136/bcr-2016-219043
Source DB: PubMed Journal: BMJ Case Rep ISSN: 1757-790X