Literature DB >> 2868746

Lack of effect of nizatidine on hepatic drug metabolism in man.

J W Secor, K V Speeg, C G Meredith, R F Johnson, P Snowdy, S Schenker.   

Abstract

The effect of nizatidine, a new H2-receptor antagonist, on the hepatic metabolism of three probe drugs was studied in normal volunteers. The drugs studied were chlordiazepoxide and theophylline which are metabolized in part by N-demethylation by the hepatic microsomal cytochrome P-450 system and lorazepam which is conjugated to lorazepam glucuronide. A 7 day course of nizatidine did not interfere with the disposition of any of these therapeutic agents in man.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2868746      PMCID： PMC1400832          DOI： 10.1111/j.1365-2125.1985.tb05136.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  14 in total

1.  Commentary: a physiological approach to hepatic drug clearance.

Authors:  G R Wilkinson; D G Shand
Journal:  Clin Pharmacol Ther       Date:  1975-10       Impact factor: 6.875

2.  Effects of aging and liver disease on disposition of lorazepam.

Authors:  J W Kraus; P V Desmond; J P Marshall; R F Johnson; S Schenker; G R Wilkinson
Journal:  Clin Pharmacol Ther       Date:  1978-10       Impact factor: 6.875

3.  High-pressure liquid chromatographic determination of chloridazepoxide and its major metabolites in biological fluids.

Authors:  M A Peat; B S Finkle; M E Deyman
Journal:  J Pharm Sci       Date:  1979-11       Impact factor: 3.534

4.  Lack of tolerance and rapid recovery of cimetidine-inhibited chlordiazepoxide (Librium) elimination.

Authors:  R V Patwardhan; R F Johnson; A P Sinclair; S Schenker; K V Speeg
Journal:  Gastroenterology       Date:  1981-09       Impact factor: 22.682

5.  Inhibition of microsomal drug metabolism by histamine H2-receptor antagonists studied in vivo and in vitro in rodents.

Authors:  K V Speeg; R V Patwardhan; G R Avant; M C Mitchell; S Schenker
Journal:  Gastroenterology       Date:  1982-01       Impact factor: 22.682

6.  Cimetidine impairs elimination of chlordiazepoxide (Librium) in man.

Authors:  P V Desmond; R V Patwardhan; S Schenker; K V Speeg
Journal:  Ann Intern Med       Date:  1980-08       Impact factor: 25.391

7.  Effects of caffeine on plasma renin activity, catecholamines and blood pressure.

Authors:  D Robertson; J C Frölich; R K Carr; J T Watson; J W Hollifield; D G Shand; J A Oates
Journal:  N Engl J Med       Date:  1978-01-26       Impact factor: 91.245

8.  Plasma binding of benzodiazepines in humans.

Authors:  R F Johnson; S Schenker; R K Roberts; P V Desmond; G R Wilkinson
Journal:  J Pharm Sci       Date:  1979-10       Impact factor: 3.534

9.  Intravenous nizatidine kinetics and acid suppression.

Authors:  J T Callaghan; R F Bergstrom; B D Obermeyer; E P King; W W Offen
Journal:  Clin Pharmacol Ther       Date:  1985-02       Impact factor: 6.875

10.  Cimetidine impairs the elimination of theophylline and antipyrine.

Authors:  R K Roberts; J Grice; L Wood; V Petroff; C McGuffie
Journal:  Gastroenterology       Date:  1981-07       Impact factor: 22.682
View more
  9 in total

Review 1.  Nizatidine. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in peptic ulcer disease.

Authors:  A H Price; R N Brogden
Journal:  Drugs       Date:  1988-11       Impact factor: 9.546

Review 2.  Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part II).

Authors:  K Lauritsen; L S Laursen; J Rask-Madsen
Journal:  Clin Pharmacokinet       Date:  1990-08       Impact factor: 6.447

3.  Nizatidine (300 mg nocte) does not interfere with diazepam pharmacokinetics in man.

Authors:  U Klotz; H G Dammann; W R Gottlieb; T A Walter; P Keohane
Journal:  Br J Clin Pharmacol       Date:  1987-01       Impact factor: 4.335

Review 4.  Newer H2-receptor antagonists. Clinical pharmacokinetics and drug interaction potential.

Authors:  D R Krishna; U Klotz
Journal:  Clin Pharmacokinet       Date:  1988-10       Impact factor: 6.447

5.  Do nizatidine and cimetidine interact with ibuprofen?

Authors:  D R Forsyth; K S Jayasinghe; C J Roberts
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

6.  Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.

Authors:  Shuang Wang; Bing Wu; Jia Xue; Ming Wang; Ruiai Chen; Bin Wang
Journal:  Hum Vaccin Immunother       Date:  2013-11-19       Impact factor: 3.452

Review 7.  Influence of endogenous and exogenous effectors on the pharmacokinetics of theophylline. Focus on biotransformation.

Authors:  U Tröger; F P Meyer
Journal:  Clin Pharmacokinet       Date:  1995-04       Impact factor: 6.447

8.  Gastric fluid volume and pH after nizatidine in adults undergoing elective surgery: influence of timing and dose.

Authors:  K Mikawa; K Nishina; N Maekawa; M Asano; H Obara
Journal:  Can J Anaesth       Date:  1995-08       Impact factor: 5.063

Review 9.  Adverse reactions and interactions with H2-receptor antagonists.

Authors:  J Penston; K G Wormsley
Journal:  Med Toxicol       Date:  1986 May-Jun
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.