<p> BACKGROUND: There are few studies on the natural history of acne lesions including the antecedents of atrophic scars.</p> <p>STUDY DESIGN: Prospective study of relationship between primary (papules, pustules, comedones) and secondary lesions (atrophic scars, macular erythema, and hyperpigmentation) over 6 months. Subjects (n=32) had moderate facial acne including 10 or more atrophic acne scars and were their own control via randomized split-face design. Lesions were mapped 2x/week for 2 months and every 2 weeks thereafter until month 6 to track pathogenic progression.</p> <p> RESULTS: Clinical assessment showed acne scars continuously forming throughout the 6-month study period. While the majority (66.2%) of these scars did not resolve by study endpoint, the remainder were transient. The likelihood of a scar developing from a primary acne lesion was 5.7%, and almost all scars arose from erythematous macules or hyperpigmentation (83%) and some (16%) developed directly from papules and pustules. Duration of papules was a key factor in the risk of scarring. The majority (81.7%) of the scars remaining at 6 months were still present at 2-year follow-up.</p> <p> CONCLUSIONS:Atrophic acne scars continuously form, some resolve, and evolve primarily from inflammatory and post-inflammatory lesions. Clinicians should closely monitor patients with macular erythema for scarring.</p> <p><em>J Drugs Dermatol. 2017;16(6):566-572.</em></p>.
RCT Entities:
<p> BACKGROUND: There are few studies on the natural history of acne lesions including the antecedents of atrophic scars.</p> <p>STUDY DESIGN: Prospective study of relationship between primary (papules, pustules, comedones) and secondary lesions (atrophic scars, macular erythema, and hyperpigmentation) over 6 months. Subjects (n=32) had moderate facial acne including 10 or more atrophic acne scars and were their own control via randomized split-face design. Lesions were mapped 2x/week for 2 months and every 2 weeks thereafter until month 6 to track pathogenic progression.</p> <p> RESULTS: Clinical assessment showed acne scars continuously forming throughout the 6-month study period. While the majority (66.2%) of these scars did not resolve by study endpoint, the remainder were transient. The likelihood of a scar developing from a primary acne lesion was 5.7%, and almost all scars arose from erythematous macules or hyperpigmentation (83%) and some (16%) developed directly from papules and pustules. Duration of papules was a key factor in the risk of scarring. The majority (81.7%) of the scars remaining at 6 months were still present at 2-year follow-up.</p> <p> CONCLUSIONS:Atrophic acne scars continuously form, some resolve, and evolve primarily from inflammatory and post-inflammatory lesions. Clinicians should closely monitor patients with macular erythema for scarring.</p> <p><em>J Drugs Dermatol. 2017;16(6):566-572.</em></p>.
Authors: Nada Elbuluk; Pearl Grimes; Anna Chien; Iltefat Hamzavi; Andrew Alexis; Susan Taylor; Noelani Gonzalez; Jonathan Weiss; Seemal R Desai; Sewon Kang Journal: Am J Clin Dermatol Date: 2021-09-01 Impact factor: 7.403
Authors: Alison Layton; Andrew Alexis; Hilary Baldwin; Stefan Beissert; Vincenzo Bettoli; James Del Rosso; Brigitte Dréno; Linda Stein Gold; Julie Harper; Charles Lynde; Diane Thiboutot; Jonathan Weiss; Jerry Tan Journal: JAAD Int Date: 2021-08-17
Authors: Brigitte Dréno; Robert Bissonnette; Angélique Gagné-Henley; Benjamin Barankin; Charles Lynde; Nabil Kerrouche; Jerry Tan Journal: Am J Clin Dermatol Date: 2018-04 Impact factor: 7.403