Literature DB >> 28685788

C-Peptide replacement therapy in type 1 diabetes: are we in the trough of disillusionment?

C W Pinger1, K E Entwistle2, T M Bell1, Y Liu2, D M Spence1.   

Abstract

Type 1 diabetes is associated with such complications as blindness, kidney failure, and nerve damage. Replacing C-peptide, a hormone normally co-secreted with insulin, has been shown to reduce diabetes-related complications. Interestingly, after nearly 30 years of positive research results, C-peptide is still not being co-administered with insulin to diabetic patients. The following review discusses the potential of C-peptide as an auxilliary replacement therapy and why it's not currently being used as a therapeutic.

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Year:  2017        PMID： 28685788      PMCID： PMC5796410          DOI： 10.1039/c7mb00199a

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  38 in total

1.  Further Clinical Experience with Insulin (Pancreatic Extracts) in the Treatment of Diabetes Mellitus.

Authors:  F G Banting; W R Campbell; A A Fletcher
Journal:  Br Med J       Date:  1923-01-06

2.  Long-Acting C-Peptide and Neuropathy in Type 1 Diabetes: A 12-Month Clinical Trial.

Authors:  John Wahren; Howard Foyt; Mark Daniels; Joseph C Arezzo
Journal:  Diabetes Care       Date:  2016-02-16       Impact factor: 19.112

3.  Studies of the diabetogenic action of streptozotocin.

Authors:  A Junod; A E Lambert; L Orci; R Pictet; A E Gonet; A E Renold
Journal:  Proc Soc Exp Biol Med       Date:  1967-10

4.  C-peptide binding to human cell membranes: importance of Glu27.

Authors:  A Pramanik; K Ekberg; Z Zhong; J Shafqat; M Henriksson; O Jansson; A Tibell; M Tally; J Wahren; H Jörnvall; R Rigler; J Johansson
Journal:  Biochem Biophys Res Commun       Date:  2001-06-01       Impact factor: 3.575

Review 5.  The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model.

Authors:  Gina L C Yosten; Grant R Kolar
Journal:  Physiology (Bethesda)       Date:  2015-07

6.  Mass spectrometric characterization and activity of zinc-activated proinsulin C-peptide and C-peptide mutants.

Authors:  Zachary Keltner; Jennifer A Meyer; Erin M Johnson; Amanda M Palumbo; Dana M Spence; Gavin E Reid
Journal:  Analyst       Date:  2009-12-04       Impact factor: 4.616

Review 7.  Advanced glycation end-products (AGEs) and heart failure: pathophysiology and clinical implications.

Authors:  Jasper W L Hartog; Adriaan A Voors; Stephan J L Bakker; Andries J Smit; Dirk J van Veldhuisen
Journal:  Eur J Heart Fail       Date:  2007-12       Impact factor: 15.534

8.  Metal-activated C-peptide facilitates glucose clearance and the release of a nitric oxide stimulus via the GLUT1 transporter.

Authors:  J A Meyer; J M Froelich; G E Reid; W K A Karunarathne; D M Spence
Journal:  Diabetologia       Date:  2007-10-27       Impact factor: 10.122

9.  Evidence for an interaction between proinsulin C-peptide and GPR146.

Authors:  Gina L C Yosten; Grant R Kolar; Lauren J Redlinger; Willis K Samson
Journal:  J Endocrinol       Date:  2013-07-11       Impact factor: 4.286

10.  C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients.

Authors:  Thomas Hach; Thomas Forst; Thomas Kunt; Karin Ekberg; Andreas Pfützner; John Wahren
Journal:  Exp Diabetes Res       Date:  2008
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  4 in total

Review 1.  Biological Activity of c-Peptide in Microvascular Complications of Type 1 Diabetes-Time for Translational Studies or Back to the Basics?

Authors:  Aleksandra Ryk; Aleksandra Łosiewicz; Arkadiusz Michalak; Wojciech Fendler
Journal:  Int J Mol Sci       Date:  2020-12-20       Impact factor: 5.923

2.  The Theory of Hyperlipidemic Memory of Type 1 Diabetes.

Authors:  Benjamin Udoka Nwosu
Journal:  Front Endocrinol (Lausanne)       Date:  2022-03-31       Impact factor: 6.055

3.  Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect.

Authors:  Juntao Yin; Yantao Hou; Yuyun Yin; Xiaoyong Song
Journal:  Int J Nanomedicine       Date:  2017-12-06

4.  Biological activity versus physiological function of proinsulin C-peptide.

Authors:  Michael Landreh; Hans Jörnvall
Journal:  Cell Mol Life Sci       Date:  2020-09-21       Impact factor: 9.261
  4 in total

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