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Literature DB >> 28685779

An esterase-activated click and release approach to metal-free CO-prodrugs.

Xingyue Ji¹, Kaili Ji, Vayou Chittavong, Bingchen Yu, Zhixiang Pan, Binghe Wang.

Abstract

One major challenge in the development of CO as a therapeutic agent is its controllable delivery in a pharmaceutically acceptable form. Herein, we describe for the first time a general chemical strategy to esterase-sensitive organic CO-prodrugs.

Entities: Chemical

Mesh：

Substances：

Year: 2017 PMID： 28685779 DOI： 10.1039/c7cc03832a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

15 in total

1. Visible-Light-Activated Quinolone Carbon-Monoxide-Releasing Molecule: Prodrug and Albumin-Assisted Delivery Enables Anticancer and Potent Anti-Inflammatory Effects.

Authors: Marina Popova; Tatiana Soboleva; Suliman Ayad; Abby D Benninghoff; Lisa M Berreau
Journal: J Am Chem Soc Date: 2018-07-23 Impact factor: 15.419

Review 2. Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response.

Authors: Zhengnan Yuan; Ladie Kimberly De La Cruz; Xiaoxiao Yang; Binghe Wang
Journal: Pharmacol Rev Date: 2022-07 Impact factor: 18.923

3. Flavonol-Based Carbon Monoxide Delivery Molecule with Endoplasmic Reticulum, Mitochondria, And Lysosome Localization.

Authors: Livia S Lazarus; C Taylor Dederich; Stephen N Anderson; Abby D Benninghoff; Lisa M Berreau
Journal: ACS Med Chem Lett Date: 2022-02-01 Impact factor: 4.632

4. Towards "CO in a pill": Pharmacokinetic studies of carbon monoxide prodrugs in mice.

Authors: Minjia Wang; Xiaoxiao Yang; Zhixiang Pan; Yingzhe Wang; Ladie Kimberly De La Cruz; Binghe Wang; Chalet Tan
Journal: J Control Release Date: 2020-08-01 Impact factor: 9.776

5. Nitro reduction-based fluorescent probes for carbon monoxide require reactivity involving a ruthenium carbonyl moiety.

Authors: Zhengnan Yuan; Xiaoxiao Yang; Ladie Kimberly De La Cruz; Binghe Wang
Journal: Chem Commun (Camb) Date: 2020-02-18 Impact factor: 6.222

An esterase-activated click and release approach to metal-free CO-prodrugs.

1. Visible-Light-Activated Quinolone Carbon-Monoxide-Releasing Molecule: Prodrug and Albumin-Assisted Delivery Enables Anticancer and Potent Anti-Inflammatory Effects.

Review 2. Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response.

3. Flavonol-Based Carbon Monoxide Delivery Molecule with Endoplasmic Reticulum, Mitochondria, And Lysosome Localization.

4. Towards "CO in a pill": Pharmacokinetic studies of carbon monoxide prodrugs in mice.

5. Nitro reduction-based fluorescent probes for carbon monoxide require reactivity involving a ruthenium carbonyl moiety.

6. Upregulation of p53 through induction of MDM2 degradation: Amino acid prodrugs of anthraquinone analogs.

Review 7. Microbial esterases and ester prodrugs: An unlikely marriage for combating antibiotic resistance.

8. Activated charcoal dispersion of carbon monoxide prodrugs for oral delivery of CO in a pill.

Review 9. Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles.

10. Red Light-Triggered CO Release from Mn₂(CO)₁₀ Using Triplet Sensitization in Polymer Nonwoven Fabrics.