Kylie H Kang1, Jimmy T Efird2, Neelesh Sharma3, Michael Yang3, Afshin Dowlati3, Philip Linden3, Mitchell Machtay4, Tithi Biswas4. 1. School of Medicine, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, USA. 2. Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, 1 Kookaburra Circuit, New Lambton Heights, NSW, 2305, Australia. 3. University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, USA. 4. Department of Radiation Oncology, University Hospitals Seidman Cancer Center, University Hospitals Cleveland Medical Center, 11100 Euclid Ave., Cleveland, OH, USA.
Abstract
AIM: Studies have shown increased pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios to be predictive of survival in various cancers. Our aim was to evaluate the prognostic role of such inflammatory markers in non-small-cell lung cancer (NSCLC). METHODS: One hundred and sixty-three patients with stage III NSCLC who received definitive treatment were included. Survival analysis was performed using Kaplan-Meier method. Hazard ratios for overall and recurrence-free survival were estimated using Cox proportional hazards model. RESULTS: Both neutrophil-to-lymphocyte >Q75 (4.5) and lymphocyte nadir values <Q25 (0.25) and their unified values were associated with 90% increased overall mortality risk (p = 0.040) and a nonsignificant 50% decreased recurrence-free survival risk. CONCLUSION: Our exploratory analysis showed markers of systemic inflammation predicted survival outcomes in advanced NSCLC. Future prospective data analyses are needed to confirm this potential.
AIM: Studies have shown increased pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios to be predictive of survival in various cancers. Our aim was to evaluate the prognostic role of such inflammatory markers in non-small-cell lung cancer (NSCLC). METHODS: One hundred and sixty-three patients with stage III NSCLC who received definitive treatment were included. Survival analysis was performed using Kaplan-Meier method. Hazard ratios for overall and recurrence-free survival were estimated using Cox proportional hazards model. RESULTS: Both neutrophil-to-lymphocyte >Q75 (4.5) and lymphocyte nadir values <Q25 (0.25) and their unified values were associated with 90% increased overall mortality risk (p = 0.040) and a nonsignificant 50% decreased recurrence-free survival risk. CONCLUSION: Our exploratory analysis showed markers of systemic inflammation predicted survival outcomes in advanced NSCLC. Future prospective data analyses are needed to confirm this potential.
Entities:
Keywords:
NSCLC; inflammatory serum markers; prognostic model
Authors: Tithi Biswas; Kylie H Kang; Rohin Gawdi; David Bajor; Mitchell Machtay; Charu Jindal; Jimmy T Efird Journal: Int J Environ Res Public Health Date: 2020-10-30 Impact factor: 3.390
Authors: Kylie H Kang; Jimmy T Efird; Tarun K Podder; Yuxia Zhang; Afshin Dowlati; Mitchell Machtay; Charulata Jindal; Tithi Biswas Journal: Int J Environ Res Public Health Date: 2021-03-21 Impact factor: 3.390