| Literature DB >> 28684381 |
Chun-Yu Liu1, Chia-Yun Wu1, Karineh Petrossian2, Tzu-Ting Huang3, Ling-Ming Tseng4, Shiuan Chen5.
Abstract
Endocrine resistance remains a challenge and an unmet need for managing hormone receptor-positive breast cancer. The mechanisms of endocrine resistance are multifaceted and are likely to evolve over time following various single or combination therapies. The purpose of this review article is to provide general understanding of molecular basis of endocrine resistance of breast cancer and to offer comprehensive review on current treatment options and potential new treatment strategies for endocrine resistant breast cancers. Last but not the least, we discuss current challenges and future directions for management of endocrine resistant breast cancers.Entities:
Keywords: Breast cancer; Endocrine resistance; Estrogen receptor; Hormone receptor
Mesh:
Substances:
Year: 2017 PMID: 28684381 DOI: 10.1016/j.jsbmb.2017.07.001
Source DB: PubMed Journal: J Steroid Biochem Mol Biol ISSN: 0960-0760 Impact factor: 4.292