Q Lin1, Z-H Lin2, J Chen3, J-X Lin2, X Li2, J-R Jiang2, X-K Ma2, D-H Wu2, Z-H Chen2, M Dong2, L Wei2, T-T Wang2, D-Y Ruan2, Z-X Lin2, J-Y Wen2, X-Y Wu2, M-S Huang4. 1. Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, 600, Tianhe Road, 510630 Guangzhou, People's Republic of China. Electronic address: linqu@mail.sysu.edu.cn. 2. Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, 600, Tianhe Road, 510630 Guangzhou, People's Republic of China. 3. Department of Oncology, Central Hospital of Hengyang, Hengyang, 421001 Hunan, People's Republic of China. 4. Department of Interventional Radiology, the Third Affiliated Hospital of Sun Yat-sen University, 600, Tianhe Road, 510630 Guangzhou, People's Republic of China. Electronic address: huangmsh@mail.sysu.edu.cn.
Abstract
BACKGROUND: This study aimed to assess the prognostic value of the serum albumin to globulin ratio (AGR) in cholangiocarcinoma patients after surgery. METHODS: We retrospectively enrolled 123 cholangiocarcinoma patients who underwent surgical treatment between June 2003 and September2014 at the Third Affiliated Hospital of Sun Yat-sen University. Univariate and multivariate analyses using the Cox regression model were performed to determine the prognostic value of AGR. RESULTS: Univariate analysis suggested that AGR was a predictive factor for (overall survival) OS but not for recurrence free survival (RFS). After adjustment for other risk factors, multivariate analysis showed that AGR remained independently associated with OS. The optimal cut-off point for AGR was determined to be 1.44. Kaplan-Meier curves showed that there was a significantly lower mean survival time in the low AGR group compared to the high AGR group. A low AGR was found to be significantly associated with high alkaline phosphatase, gamma-glutamyl transpeptidase, total bilirubin levels and an advanced American Joint Committee on Cancer TNM stage, but a low hemoglobin level. CONCLUSION: In summary, patients with higher AGRs have better outcomes than those with lower AGRs. Preoperative AGR can be a reliable marker for evaluating the prognosis of cholangiocarcinoma patients.
BACKGROUND: This study aimed to assess the prognostic value of the serum albumin to globulin ratio (AGR) in cholangiocarcinomapatients after surgery. METHODS: We retrospectively enrolled 123 cholangiocarcinomapatients who underwent surgical treatment between June 2003 and September2014 at the Third Affiliated Hospital of Sun Yat-sen University. Univariate and multivariate analyses using the Cox regression model were performed to determine the prognostic value of AGR. RESULTS: Univariate analysis suggested that AGR was a predictive factor for (overall survival) OS but not for recurrence free survival (RFS). After adjustment for other risk factors, multivariate analysis showed that AGR remained independently associated with OS. The optimal cut-off point for AGR was determined to be 1.44. Kaplan-Meier curves showed that there was a significantly lower mean survival time in the low AGR group compared to the high AGR group. A low AGR was found to be significantly associated with high alkaline phosphatase, gamma-glutamyl transpeptidase, total bilirubin levels and an advanced American Joint Committee on Cancer TNM stage, but a low hemoglobin level. CONCLUSION: In summary, patients with higher AGRs have better outcomes than those with lower AGRs. Preoperative AGR can be a reliable marker for evaluating the prognosis of cholangiocarcinomapatients.