Literature DB >> 28684173

Revolution of Resting-State Functional Neuroimaging Genetics in Alzheimer's Disease.

Patrizia A Chiesa1, Enrica Cavedo2, Simone Lista3, Paul M Thompson4, Harald Hampel5.   

Abstract

The quest to comprehend genetic, biological, and symptomatic heterogeneity underlying Alzheimer's disease (AD) requires a deep understanding of mechanisms affecting complex brain systems. Neuroimaging genetics is an emerging field that provides a powerful way to analyze and characterize intermediate biological phenotypes of AD. Here, we describe recent studies showing the differential effect of genetic risk factors for AD on brain functional connectivity in cognitively normal, preclinical, prodromal, and AD dementia individuals. Functional neuroimaging genetics holds particular promise for the characterization of preclinical populations; target populations for disease prevention and modification trials. To this end, we emphasize the need for a paradigm shift towards integrative disease modeling and neuroimaging biomarker-guided precision medicine for AD and other neurodegenerative diseases.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Alzheimer’s disease; functional connectivity; genetic risk; neuroimaging genetics; precision medicine

Mesh：

Year:  2017        PMID： 28684173      PMCID： PMC5798613          DOI： 10.1016/j.tins.2017.06.002

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  83 in total

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3.  APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42.

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Review 4.  Are the dorsal and ventral hippocampus functionally distinct structures?

Authors:  Michael S Fanselow; Hong-Wei Dong
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Review 5.  Epidemiology of Alzheimer disease.

Authors:  Christiane Reitz; Carol Brayne; Richard Mayeux
Journal:  Nat Rev Neurol       Date:  2011-02-08       Impact factor: 42.937

Review 6.  Alzheimer's disease as homeostatic responses to age-related myelin breakdown.

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Journal:  Neurobiol Aging       Date:  2009-09-22       Impact factor: 4.673

Review 7.  Brain connectivity in neurodegenerative diseases--from phenotype to proteinopathy.

Authors:  Michela Pievani; Nicola Filippini; Martijn P van den Heuvel; Stefano F Cappa; Giovanni B Frisoni
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Review 8.  Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease.

Authors:  Stefan J Teipel; Michel Grothe; Simone Lista; Nicola Toschi; Francesco G Garaci; Harald Hampel
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9.  BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks.

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Review 1.  Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology.

Authors:  Harald Hampel; Nicola Toschi; Claudio Babiloni; Filippo Baldacci; Keith L Black; Arun L W Bokde; René S Bun; Francesco Cacciola; Enrica Cavedo; Patrizia A Chiesa; Olivier Colliot; Cristina-Maria Coman; Bruno Dubois; Andrea Duggento; Stanley Durrleman; Maria-Teresa Ferretti; Nathalie George; Remy Genthon; Marie-Odile Habert; Karl Herholz; Yosef Koronyo; Maya Koronyo-Hamaoui; Foudil Lamari; Todd Langevin; Stéphane Lehéricy; Jean Lorenceau; Christian Neri; Robert Nisticò; Francis Nyasse-Messene; Craig Ritchie; Simone Rossi; Emiliano Santarnecchi; Olaf Sporns; Steven R Verdooner; Andrea Vergallo; Nicolas Villain; Erfan Younesi; Francesco Garaci; Simone Lista
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2.  Common variants contribute to intrinsic human brain functional networks.

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3.  Virtual Connectomic Datasets in Alzheimer's Disease and Aging Using Whole-Brain Network Dynamics Modelling.

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4.  Effects of gene mutation and disease progression on representative neural circuits in familial Alzheimer's disease.

Authors:  Meina Quan; Tan Zhao; Yi Tang; Ping Luo; Wei Wang; Qi Qin; Tingting Li; Qigeng Wang; Jiliang Fang; Jianping Jia
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5.  Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease.

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6.  Gene co-expression changes underlying the functional connectomic alterations in Alzheimer's disease.

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Review 7.  The human connectome in Alzheimer disease - relationship to biomarkers and genetics.

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8.  Default Mode Network Analysis of APOE Genotype in Cognitively Unimpaired Subjects Based on Persistent Homology.

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9.  BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females.

Authors:  Inmaculada C Rodríguez-Rojo; Pablo Cuesta; María Eugenia López; Jaisalmer de Frutos-Lucas; Ricardo Bruña; Ernesto Pereda; Ana Barabash; Pedro Montejo; Mercedes Montenegro-Peña; Alberto Marcos; Ramón López-Higes; Alberto Fernández; Fernando Maestú
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10.  Resting-state default mode network connectivity in young individuals with Down syndrome.

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  10 in total

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