Literature DB >> 28683284

Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

Frances M Ashcroft1, Maria Rohm2, Anne Clark3, Melissa F Brereton2.   

Abstract

Elevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting β cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in β cells in normoglycemia and in diabetes.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  diabetes; glycogen; insulin; pancreatic β cell

Mesh：

Substances：

Year:  2017        PMID： 28683284      PMCID： PMC5890904          DOI： 10.1016/j.cmet.2017.05.014

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  77 in total

1.  Pathogenesis of glycogen infiltration of the pancreas in diabetes.

Authors:  S S LAZARUS; B W VOLK
Journal:  Diabetes       Date:  1958 Jan-Feb       Impact factor: 9.461

2.  Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.

Authors:  Sharona Tornovsky-Babeay; Daniela Dadon; Oren Ziv; Elhanan Tzipilevich; Tehila Kadosh; Rachel Schyr-Ben Haroush; Ayat Hija; Miri Stolovich-Rain; Judith Furth-Lavi; Zvi Granot; Shay Porat; Louis H Philipson; Kevan C Herold; Tricia R Bhatti; Charles Stanley; Frances M Ashcroft; Peter In't Veld; Ann Saada; Mark A Magnuson; Benjamin Glaser; Yuval Dor
Journal:  Cell Metab       Date:  2013-12-12       Impact factor: 27.287

3.  Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.

Authors:  M Anello; R Lupi; D Spampinato; S Piro; M Masini; U Boggi; S Del Prato; A M Rabuazzo; F Purrello; P Marchetti
Journal:  Diabetologia       Date:  2005-01-15       Impact factor: 10.122

4.  Presence and mobilization of glycogen in mammalian pancreatic beta cells.

Authors:  B Hellman; L A Idahl
Journal:  Endocrinology       Date:  1969-01       Impact factor: 4.736

5.  Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.

Authors:  Chutima Talchai; Shouhong Xuan; Hua V Lin; Lori Sussel; Domenico Accili
Journal:  Cell       Date:  2012-09-14       Impact factor: 41.582

6.  Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes.

Authors:  J C Jonas; A Sharma; W Hasenkamp; H Ilkova; G Patanè; R Laybutt; S Bonner-Weir; G C Weir
Journal:  J Biol Chem       Date:  1999-05-14       Impact factor: 5.157

7.  Dynamics of glucose-induced insulin secretion in normal human islets.

Authors:  Jean-Claude Henquin; Denis Dufrane; Julie Kerr-Conte; Myriam Nenquin
Journal:  Am J Physiol Endocrinol Metab       Date:  2015-08-11       Impact factor: 4.310

8.  Protein targeting to glycogen overexpression results in the specific enhancement of glycogen storage in 3T3-L1 adipocytes.

Authors:  Cynthia C Greenberg; Kimberly N Meredith; Limei Yan; Matthew J Brady
Journal:  J Biol Chem       Date:  2003-06-12       Impact factor: 5.157

9.  Destruction of tissue, cells and organelles in type 1 diabetic rats presented at macromolecular resolution.

Authors:  Raimond B G Ravelli; Ruby D Kalicharan; M Cristina Avramut; Klaas A Sjollema; Joachim W Pronk; Freark Dijk; Abraham J Koster; Jeroen T J Visser; Frank G A Faas; Ben N G Giepmans
Journal:  Sci Rep       Date:  2013       Impact factor: 4.379

10.  Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes.

Authors:  Åsa Segerstolpe; Athanasia Palasantza; Pernilla Eliasson; Eva-Marie Andersson; Anne-Christine Andréasson; Xiaoyan Sun; Simone Picelli; Alan Sabirsh; Maryam Clausen; Magnus K Bjursell; David M Smith; Maria Kasper; Carina Ämmälä; Rickard Sandberg
Journal:  Cell Metab       Date:  2016-09-22       Impact factor: 27.287
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  19 in total

1.  Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.

Authors:  Buyun Tang; Mykhaylo S Frasinyuk; Vimbai M Chikwana; Krishna K Mahalingan; Cynthia A Morgan; Dyann M Segvich; Svitlana P Bondarenko; Galyna P Mrug; Przemyslaw Wyrebek; David S Watt; Anna A DePaoli-Roach; Peter J Roach; Thomas D Hurley
Journal:  J Med Chem       Date:  2020-03-23       Impact factor: 7.446

2.  Placental diabesity: placental VEGF and CD31 expression according to pregestational BMI and gestational weight gain in women with gestational diabetes.

Authors:  Dario Pitocco; Antonio Lanzone; Angelo Sirico; Esther Diana Rossi; Valentina Anna Degennaro; Vincenzo Arena; Alessandro Rizzi; Linda Tartaglione; Mauro Di Leo
Journal:  Arch Gynecol Obstet       Date:  2022-07-14       Impact factor: 2.493

Review 3.  Effects of Dietary Fatty Acids in Pancreatic Beta Cell Metabolism, Implications in Homeostasis.

Authors:  Paloma Acosta-Montaño; Víctor García-González
Journal:  Nutrients       Date:  2018-03-22       Impact factor: 5.717

4.  Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.

Authors:  Elizabeth Haythorne; Maria Rohm; Martijn van de Bunt; Melissa F Brereton; Andrei I Tarasov; Thomas S Blacker; Gregor Sachse; Mariana Silva Dos Santos; Raul Terron Exposito; Simon Davis; Otto Baba; Roman Fischer; Michael R Duchen; Patrik Rorsman; James I MacRae; Frances M Ashcroft
Journal:  Nat Commun       Date:  2019-06-06       Impact factor: 14.919

Review 5.  Glucose and glycogen in the diabetic kidney: Heroes or villains?

Authors:  Mitchell A Sullivan; Josephine M Forbes
Journal:  EBioMedicine       Date:  2019-08-10       Impact factor: 8.143

Review 6.  Glucose as a Major Antioxidant: When, What for and Why It Fails?

Authors:  Andriy Cherkas; Serhii Holota; Tamaz Mdzinarashvili; Rosita Gabbianelli; Neven Zarkovic
Journal:  Antioxidants (Basel)       Date:  2020-02-05

7.  Anti-Diabetic Nephropathy Activities of Polysaccharides Obtained from Termitornyces albuminosus via Regulation of NF-κB Signaling in db/db Mice.

Authors:  Chang Yang; Qi Feng; Huan Liao; Xinlei Yu; Yang Liu; Di Wang
Journal:  Int J Mol Sci       Date:  2019-10-21       Impact factor: 5.923

8.  Streptozotocin induces brain glucose metabolic changes and alters glucose transporter expression in the Lobster cockroach; Nauphoeta cinerea (Blattodea: Blaberidae).

Authors:  Olawande C Olagoke; Blessing A Afolabi; João B T Rocha
Journal:  Mol Cell Biochem       Date:  2020-11-20       Impact factor: 3.396

Review 9.  The Pathophysiology of Gestational Diabetes Mellitus.

Authors:  Jasmine F Plows; Joanna L Stanley; Philip N Baker; Clare M Reynolds; Mark H Vickers
Journal:  Int J Mol Sci       Date:  2018-10-26       Impact factor: 5.923

Review 10.  Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities.

Authors:  Lucas Opazo-Ríos; Sebastián Mas; Gema Marín-Royo; Sergio Mezzano; Carmen Gómez-Guerrero; Juan Antonio Moreno; Jesús Egido
Journal:  Int J Mol Sci       Date:  2020-04-10       Impact factor: 5.923
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