Importance of "reciprocal" electrocardiographic changes during occlusion of left anterior descending coronary artery. Studies during percutaneous transluminal coronary angioplasty.

ST-segment depression remote from the region of acute myocardial infarction was investigated in three groups of patients undergoing left anterior descending coronary angioplasty. Ten patients had single-vessel disease, nine concomitant stenoses in one or more other major coronary arteries, and two myocardial infarction after occlusion during angioplasty. Continuous surface electrocardiograms were recorded from leads I, II, III, v2, and v5, before, during, and after coronary angioplasty and ST-segment changes were measured to 0.1 mm. All ten patients with single-vessel disease had ST-segment elevation in lead v2 and nine also had changes in lead III. All nine patients with multivessel disease had ST-segment changes in lead v2; eight of them had concomitant changes in lead III. Both patients with myocardial infarction had elevation in lead v2 and depression in lead III. ST-segment changes began simultaneously in all leads where they occurred. Most (70%) patients with single-vessel disease who had inferior ST-segment depression had a right-dominant coronary circulation. Therefore, the presence of inferior ST-segment depression during left anterior descending coronary artery occlusion does not indicate the presence or absence of multivessel disease. Furthermore, it is unlikely that this change always represents ischaemia remote from the site of infarction; it is merely an electrical phenomenon.